银杏叶提取物注射液联合依达拉奉治疗脑梗死后轻中度认知功能障碍患者的效果

Effects of extract of ginkgo biloba leaves injection combined with Edaravone on patients with mild to moderate cognitive impairment after cerebral infarction

目的:观察银杏叶提取物注射液联合依达拉奉治疗脑梗死后轻中度认知功能障碍患者的效果。方法:选取2020年1月至2021年3月黑龙江省佳木斯市中心医院收治的80例脑梗死后轻中度认知功能障碍患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各40例。在常规治疗基础上,对照组采用依达拉奉注射液治疗,观察组在对照组基础上联合银杏叶提取物注射液治疗,比较两组疗效、美国国立卫生研究院卒中量表(NIHSS)评分、蒙特利尔认知评估量表(MoCA)评分、简易智力状况检查表(MMSE)评分、Barthel指数(BI)评分、血清炎性因子[基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)与白细胞介素-6(IL-6)]水平和不良反应发生率。结果:观察组治疗总有效率为95.00%,明显高于对照组的77.50%,差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分和MMP-9、TNF-α、IL-6水平均低于对照组,MoCA、MMSE、BI评分均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合依达拉奉治疗脑梗死后轻中度认知功能障碍患者可提高治疗总有效率、MoCA评分、BI评分和MMSE评分,降低NIHSS评分和血清炎性因子水平,效果优于单纯依达拉奉治疗。

Objective:To observe effects of extract of ginkgo biloba leaves injection combined with Edaravone on patients with mild to moderate cognitive impairment after cerebral infarction.Methods:A prospective study was conducted on 80 patients with mild to moderate cognitive impairment after cerebral infarction from January 2020 to March 2021.They were divided into observation group and control group according to the random number table method,40 cases in each group.Both groups were given basic treatment.On this basis,the control group was treated with Edaravone injection,while the observation group was treated with extract of ginkgo biloba leaves injection on the basis of that of the control group.The efficacy,the national institutes of health stroke scale(NIHSS)score,the Montreal cognitive assessment(MoCA)score,the mini-mental state examination(MMSE)score,the Barthel Index(BI)score,the serum inflammatory factor levels[matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score and the levels of MMP-9,TNF-αand IL-6 in the observation group were lower than those in the control group,the MoCA,MMSE and BI scores were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Extract of ginkgo biloba leaves injection combined with Edaravone in the treatment of the patients with mild to moderate cognitive impairment after cerebral infarction can improve the total effective rate of treatment,the MoCA score,the BI score and the MMSE score,and reduce the NIHSS score and the serum inflammatory factor levels.Moreover,it is superior to single Edaravone treatment.