戊酸雌二醇联合黄体酮胶囊治疗无排卵型月经不调患者的效果

Effects of Estradiol valerate combined with Progesterone capsules in treatment of patients with anovulatory irregular menstruation

目的:观察戊酸雌二醇联合黄体酮胶囊治疗无排卵型月经不调患者的效果。方法:选取2019年5月至2020年10月该院收治的94例无排卵型月经不调患者进行前瞻性研究。按照随机数字表法分为对照组和观察组各47例。两组均给予常规治疗,在此基础上,对照组予以戊酸雌二醇治疗,观察组予以戊酸雌二醇联合黄体酮胶囊治疗。比较两组疗效、月经时长、月经周期、子宫内膜厚度、血清性激素[孕酮(P)、雌二醇(E_(2))、促卵泡成熟激素(FSH)]水平、卵泡发育指标(卵泡直径、优质卵泡数)水平和不良反应发生率。结果:治疗后,两组月经时长、月经周期均短于治疗前,且观察组短于对照组,两组子宫内膜厚度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组FSH水平均低于治疗前,且观察组低于对照组,两组E_(2)、P水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组卵泡直径均大于治疗前,且观察组大于对照组,两组优质卵泡数均多于治疗前,且观察组多于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.64%,对照组不良反应发生率为8.51%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:戊酸雌二醇联合黄体酮胶囊治疗无排卵型月经不调患者可提高治疗总有效率及E_(2)、P和卵泡发育指标水平,缩短月经时长和月经周期,降低子宫内膜厚度和FSH水平,优于单纯戊酸雌二醇治疗效果。

Objective:To observe effects of Estradiol valerate combined with Progesterone capsules in treatment of patients with anovulatory irregular menstruation.Methods:A prospective study was conducted on 94 patients with anovulatory irregular menstruation admitted to the hospital from May 2019 to October 2020.According to random number table method,they were divided into control group and observation group,47 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Estradiol valerate,while the observation group was treated with Estradiol valerate combined with Progesterone capsules.The efficacy,the menstrual duration,the menstrual cycle,the endometrial thickness,the serum sex hormone levels[progesterone(P),estradiol(E_(2)),follicle stimulating hormone(FSH)],the follicular development indicator levels(follicle diameter,number of high-quality follicles),and incidence of adverse reactions were compared between the two groups.Results:After the treatment,the menstrual duration and the menstrual cycle of the two groups were shorter than those before the treatment,and those in the observation group were shorter than those in the control group;the endometrial thickness of the two groups was thinner than that before the treatment,and that in the observation group was thinner than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the FSH levels of the two groups were lower than those before the treatment,and that of the observation group was lower than that of the control group;the levels of E_(2) and P in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the follicle diameter of the two groups was larger than that before the treatment,and that in the observation group was larger than that in the control group;the numbers of high-quality follicles in both groups were more than those before the treatment,and that of observation group was more than that of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions was 10.64%in the observation group and 8.51%in the control group,and the difference was not statistically significant(P>0.05).Conclusions:Estradiol valerate combined with Progesterone capsules in the treatment of the patients with anovulatory irregular menstruation can improve the total effective rate and the levels of E_(2),P and follicular development indexes,shorten the menstrual duration and the menstrual cycle,and reduce the endometrial thickness and the FSH levels.Moreover,it is superior to single Estradiol valerate treatment.