神经节苷脂联合尼莫地平治疗高血压脑出血患者的临床疗效观察

Clinical observation of ganglioside combined with nimodipine in the treatment of patients with hypertensive cerebral hemorrhage

目的探讨高血压脑出血患者应用神经节苷脂联合尼莫地平治疗的临床疗效。方法142例高血压脑出血患者为研究对象,按照随机数字表法分为观察组和对照组,每组71例。对照组采用常规治疗,观察组在对照组治疗基础上给予神经节苷脂联合尼莫地平治疗。对比两组临床疗效,治疗前后炎性因子[血清白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平及不良反应发生情况。结果观察组治疗总有效率为93.0%,明显高于对照组的74.6%,差异有统计学意义(P<0.05)。治疗后,两组IL-6、CRP、TNF-α水平均明显低于本组治疗前,且观察组IL-6(40.73±5.79)μg/L、CRP(26.93±5.17)mg/L、TNF-α(32.25±7.17)μg/L均低于对照组的(55.74±8.17)μg/L、(38.05±3.77)mg/L、(43.96±7.12)μg/L,差异有统计学意义(P<0.05)。观察组不良反应发生率为7.0%,与对照组的8.5%对比,差异无统计学意义(P>0.05)。结论高血压脑出血患者应用神经节苷脂及尼莫地平治疗临床疗效确切,可减轻炎性因子水平,对促进患者康复具有显著作用。

Objective To discuss the clinical efficacy of ganglioside combined with nimodipine in the treatment of patients with hypertensive cerebral hemorrhage.Methods A total of 142 patients with hypertensive cerebral hemorrhage were selected as the research subjects,and the patients were divided into an observation group and a control group according to the random numerical table,with 71 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with ganglioside combined with nimodipine on the basis of the treatment of the control group.Both groups were compared in terms of clinical efficacy,inflammatory factors[serum interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]levels before and after treatment,and the occurrence of adverse reactions.Results The total effective rate of treatment in the observation group was 93.0%,which was significantly higher than 74.6%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6,CRP and TNF-αin the two groups were significantly lower than those before treatment in this group;the IL-6 in observation group was(40.73±5.79)μg/L,CRP was(26.93±5.17)mg/L,and TNF-αwas(32.25±7.17)μg/L,which were lower than(55.74±8.17)μg/L,(38.05±3.77)mg/L,and(43.96±7.12)μg/L in the control group;the differences were all statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 7.0%,and the difference was not statistically significant compared with 8.5%in the control group(P>0.05).Conclusion The application of ganglioside and nimodipine in the treatment of hypertensive intracerebral hemorrhage has a definite clinical effect,and can reduce the level of inflammatory factors,and has a significant effect on promoting the recovery of patients.