阿奇霉素序贯治疗小儿支原体肺炎的疗效观察

Observation on the efficacy of azithromycin sequential therapy for mycoplasma pneumonia in children

目的分析小儿支原体肺炎疾病特点,评价阿奇霉素序贯治疗的临床效果。方法80例小儿支原体肺炎患儿,以随机法分为对照组和观察组,每组40例。对照组患儿采用常规治疗,观察组患儿采用阿奇霉素序贯治疗。比较两组治疗效果、不良反应发生情况、血清炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、临床症状(咳嗽、发热、肺啰音)消失时间。结果观察组患儿的治疗总有效率为95.00%,显著高于对照组的80.00%,差异具有统计学意义(P<0.05)。观察组患儿的不良反应发生率为5.00%,显著低于对照组的25.00%,差异具有统计学意义(P<0.05)。治疗后,观察组患儿的CRP、IL-6、TNF-α分别为(5.30±0.80)mg/L、(3.65±0.70)ng/L、(8.43±1.20)ng/L,均低于对照组的(8.30±1.20)mg/L、(12.20±2.20)ng/L、(11.30±2.20)ng/L,差异具有统计学意义(P<0.05)。观察组患儿的咳嗽、发热、肺啰音消失时间分别为(3.20±0.50)、(2.20±0.50)、(4.50±1.50)d,均短于对照组的(5.30±1.20)、(3.80±1.20)、(6.50±1.50)d,差异具有统计学意义(P<0.05)。结论阿奇霉素序贯治疗小儿支原体肺炎可以促进小儿症状消失、降低血清炎性因子水平,治疗效果理想且安全性高。

Objective To analyze the clinical effect of azithromycin sequential therapy for mycoplasma pneumonia in children.Methods A total of 80 children with mycoplasma pneumonia were randomly divided into control group and observation group,with 40 cases in each group.Children in the control group received conventional therapy,while children in the observation group received azithromycin sequential therapy.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions,serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels,and disappearance time of clinical symptoms(cough,fever,pulmonary rales).Results The total effective rate in the observation group was 95.00%,which was significantly higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was significantly lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the CRP,IL-6,and TNF-αof the observation group were(5.30±0.80)mg/L,(3.65±0.70)ng/L,and(8.43±1.20)ng/L,which were lower than(8.30±1.20)mg/L,(12.20±2.20)ng/L,and(11.30±2.20)ng/L of the control group,and the differences were all statistically significant(P<0.05).The disappearance times of cough,fever and pulmonary rales in the observation group were(3.20±0.50),(2.20±0.50),and(4.50±1.50)d,which were shorter than(5.30±1.20),(3.80±1.20),and(6.50±1.50)d in the control group,and the differences were all statistically significant(P<0.05).Conclusion Azithromycin sequential therapy in children with mycoplasma pneumonia can promote the disappearance of children's symptoms and reduce the level of serum inflammatory factors,with ideal therapeutic effect and high safety.