稳心颗粒联合美托洛尔治疗冠心病合并室性心律失常的效果探讨

Discussion on the effect of Wenxin Granule combined with metoprolol in the treatment of coronary heart disease complicated with ventricular arrhythmia

目的 探讨稳心颗粒联合美托洛尔治疗冠心病合并室性心律失常的效果。方法 100例冠心病合并室性心律失常患者,以简单随机化法分为实验组与对照组,各50例。对照组给予美托洛尔治疗,实验组给予稳心颗粒联合美托洛尔治疗。比较两组临床疗效、治疗前后心功能指标、不良反应发生情况。结果 实验组治疗总有效率为96.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,两组窦性心搏间期标准差(SDNN)、窦性心搏间期平均值标准差(SDANN)、相邻正常窦性心搏间期差值的均方根(RMSSD)、50 ms的个数占总窦性心搏个数的百分比(PNN50)均较治疗前升高,且实验组SDNN(140.30±10.60)ms、SDANN(128.65±11.45)ms、RMSSD(39.40±4.10)ms、PNN50(15.75±2.85)%均高于对照组的(132.50±10.15)ms、(116.85±10.20)ms、(32.50±3.60)ms、(12.40±2.60)%,差异有统计学意义(P<0.05)。实验组不良反应发生率4.00%低于对照组的18.00%,差异有统计学意义(P<0.05)。结论 冠心病合并室性心律失常应用稳心颗粒联合美托洛尔治疗的效果显著,值得临床参考应用。

Objective To discuss the effect of Wenxin Granule combined with metoprolol in the treatment of coronary heart disease complicated with ventricular arrhythmia. Methods A total of 100 patients with coronary heart disease and ventricular arrhythmia were randomly divided into experimental group and control group, with 50 patients in each group. The control group was treated with metoprolol, and the experimental group was treated with Wenxin Granules and metoprolol. The clinical efficacy, cardiac function indexes before and after treatment, and occurrence of adverse reactions of the two groups were compared. Results The total effective rate of the experimental group was 96.00%, which was higher than 80.00% of the control group, and the difference was statistically significant(P<0.05). After treatment, the standard deviation of normal R-R intervals(SDNN), the standard deviation of the averages of NN intervals(SDANN), root mean square of successive difference(RMSSD),and the percentage of differences exceeding 50 ms between adjacent normal number of intervals(PNN50) in both groups were higher than those before treatment in this group;the SDNN(140.30±10.60) ms, SDANN(128.65±11.45) ms, RMSSD(39.40±4.10) ms, PNN50(15.75±2.85)% in the experimental group were higher than(132.50±10.15) ms,(116.85±10.20) ms,(32.50±3.60) ms,(12.40±2.60)% in the control group;the differences were statistically significant(P<0.05). The incidence of adverse reactions in the experimental group was 4.00%, which was lower than 18.00% in the control group, and the difference was statistically significant(P<0.05). Conclusion Wenxin Granule combined with metoprolol has significant therapeutic effect on coronary heart disease complicated with ventricular arrhythmia, and is worthy of clinical reference and application.