长托宁对急性有机磷农药中毒患者的疗效分析

Analysis of efficacy of Changtuoning on patients with acute organophosphorus pesticide poisoning

目的 研究盐酸戊乙奎醚注射液(商品名:长托宁)对急性有机磷农药中毒患者的疗效。方法 55例急性有机磷农药中毒患者,依据随机数字表法分为观察组(28例)与对照组(27例)。观察组采用长托宁治疗,对照组采用阿托品治疗。对比两组治愈率、时间指标、抗胆碱药使用情况及不良反应发生情况。结果 观察组治愈27例(96.43%),未愈1例(3.57%);对照组治愈19例(70.37%),未愈8例(29.63%)。观察组治愈率高于对照组,差异有统计学意义(P<0.05)。观察组患者症状消失时间(3.39±1.03)h、胆碱酯酶活力恢复时间(5.48±1.20)h、住院时间(3.69±1.22)d均短于对照组的(6.56±1.26)h、(19.39±4.31)h、(7.19±1.20)d,差异有统计学意义(P<0.05)。观察组用药总量(16.32±2.63)mg低于对照组的(76.23±4.51)mg,给药次数(8.49±1.82)次少于对照组的(25.63±4.29)次,差异有统计学意义(P<0.05)。观察组不良反应发生率3.57%低于对照组的25.93%,差异有统计学意义(P<0.05)。结论 急性有机磷农药中毒患者在长托宁治疗下,可提高治愈率,使患者症状短时间消失,缩短住院时间,减少用药总量与用药次数,不良反应较少。

Objective To study the efficacy of Penehyclidine hydrochloride injection(trade name:Changtuoning) on patients with acute organophosphorus pesticide poisoning. Methods A total of 55 patients with acute organophosphorus pesticide poisoning were divided into observation group(28 cases) and control group(27 cases) according to random numerical table. The observation group was treated with Changtuoning, and the control group was treated with atropine. The cure rate, time index, use of anticholinergic drug and occurrence of adverse reactions of the two groups were compared. Results In the observation group, 27 cases(96.43%) were cured, 1 case(3.57%) was not cured;in the control group, 19 cases(70.37%) were cured and 8 cases(29.63%)were not cured. The cure rate in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). The symptom disappearance time(3.39±1.03) h, the recovery time of cholinesterase activity(5.48±1.20) h, and the hospitalization time(3.69±1.22) d in the observation group were shorter than(6.56±1.26) h,(19.39±4.31) h, and(7.19±1.20) d in the control group, and the differences were statistically significant(P<0.05). The total amount of medication(16.32±2.63) mg in the observation group was lower than(76.23±4.51) mg in the control group, and the number of medications(8.49±1.82) times was less than(25.63±4.29) times in the control group, and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 3.57%, which was lower than 25.93% in the control group, and the difference was statistically significant(P<0.05). Conclusion Changtuoning for patients with acute organophosphorus pesticide poisoning can improve the cure rate, shorten symptoms disappearance time and hospitalization time, and reduce total amount of medication and number of medications, and the adverse reactions are less.