依达拉奉联合七叶皂苷钠治疗老年高血压脑出血引流术后患者的效果

Effects of edaravone combined with sodium aescinate on elderly patients with hypertensive intracerebral hemorrhage after drainage

目的:探究依达拉奉联合七叶皂苷钠治疗老年高血压脑出血软通道微创穿刺引流术后患者的效果。方法:选取老年高血压脑出血患者102例作为研究对象,将其随机分为两组。两组均采用软通道微创穿刺引流术治疗,对照组51例术后给予依达拉奉治疗,观察组51例在对照组基础上联合七叶皂苷钠治疗。比较两组神经功能、生活活动能力、炎症因子水平、内皮功能及不良反应。结果:治疗后,观察组神经功能及生活活动能力均优于对照组,差异有统计学意义(P<0.05);炎症因子水平均较对照组低(P<0.05);内皮功能优于对照组(P<0.05);两组不良反应比较,无统计学差异(P>0.05)。结论:七叶皂苷钠联合依达拉奉能有效抑制炎症反应,改善血管内皮功能和神经功能。

Objective: To investigate the effects of edaravone combined with sodium aescinate on elderly patients with hypertensive intracerebral hemorrhage after soft channel minimally invasive puncture and drainage. Methods: 102 elderly patients with hypertensive intracerebral hemorrhage were selected as the research objects, who were randomized into two groups. All patients in both groups were treated with soft channel minimally invasive puncture and drainage. Then, 51 cases in the control group were treated with edaravone after surgery, while another 51 cases in the observation group received sodium aescinate treatment on the basis of the control group. The neurological function, activity of daily living, inflammatory factor levels, endothelial function and adverse reactions were compared between the two groups. Results: After treatment, the improvement of neurological function and activity of daily living in the observation group was better than that in the control group, and the differences were statistically significant(P <0.05);the levels of inflammatory factors were lower than those in the control group(P<0.05);the endothelial function was better than that of the control group(P<0.05);and there was no significance of adverse reactions between both groups(P>0.05). Conclusion: Edaravone combined with sodium aescinate can effectively inhibit the inflammatory response and improve vascular endothelial function and neurological function in patients.