地诺前列酮辅助小水囊促足月妊娠宫颈成熟的应用

Application of dinoprostone assisted small water sac to promoting cervical maturation in term pregnancy

目的:探讨小水囊联合地诺前列酮对足月妊娠孕妇引产的影响。方法:将98例足月妊娠孕妇随机分为对照组和研究组。对照组采用小水囊放置术引产,研究组采用小水囊联合地诺前列酮辅助引产。分析两组Bishop评分、促宫颈成熟效果、白细胞介素-8(IL-8)、母婴结局、内皮素-1(ET-1)、不良反应、前列腺素_(2α)(PGE_(2α))、白细胞介素-1β(IL-1β)水平。结果:引产6 h、12 h,研究组Bishop评分均高于对照组,差异有统计学意义(P<0.05);研究组促宫颈成熟有效率97.96%高于对照组83.67%(P<0.05);研究组自然分娩率较对照组高,总产程用时较对照组少,剖宫产率较对照组低(P<0.05);引产12 h后,研究组IL-1β、IL-8、ET-1、PGE_(2α)水平均较对照组高(P<0.05);研究组不良反应率6.12%与对照组4.08%比较,无统计学差异(P>0.05)。结论:小水囊与地诺前列酮联合应用于足月妊娠引产可促宫颈成熟,提高自然分娩率。

Objective:To investigate the effect of small water sac combined with dinoprostone on labor induction in full-term pregnant women.Methods:A total of 98 full-term pregnant women were randomized into the control group and study group,each with 49 cases.The control group were induced by small water sac placement,while the study group were induced by small water sac combined with dinoprostone.Bishop score,promotion effect of cervical maturation,interleukin-8(IL-8),maternal and infant outcomes,endothelin-1(ET-1),adverse reactions,prostaglandin 2α(PGE_(2α))and interleukin-1β(IL-1β)levels were compared between both groups.Results:At 6 h and 12 h of labor induction,the Bishop score of the study group was higher than that of the control group,and the differences were statistically significant(P<0.05);the effective rate of promoting cervical maturation in the study group was 97.96%,higher than 83.67%in the control group(P<0.05);the natural delivery rate of the study group was higher than that of the control group,the total labor time was lower than that of the control group,and the cesarean section rate was lower than that of the control group(P<0.05);after 12 h of labor induction,the level of IL-1β,IL-8,ET-1,PGE_(2α) in the study group were higher than that in the control group(P<0.05);and there was no significant difference in the adverse reaction rate between the study group and the control group(6.12%and 4.08%respectively,P>0.05).Conclusion:The combined application of small water sac and dinoprostone in induction of labor of term pregnancy can promote cervical maturation and improve the rate of natural delivery.