康柏西普联合PRP治疗对DR患者视网膜局部微循环的影响

Effects of conbercept combined with PRP on local retinal microcirculation in patients with DR

目的:探究康柏西普眼用注射液联合全视网膜激光光凝术(PRP)对糖尿病视网膜病变(DR)患者视网膜局部微循环障碍的治疗作用。方法:选取82例DR患者,按随机数字表法分为两组,每组41例。对照组采用PRP治疗,观察组采用康柏西普联合PRP治疗。观察两组视网膜微循环情况,分析两组房水基质细胞衍生因子1(SDF-1)、血管内皮生长因子(VEGF)水平,血清炎症因子水平,视力及并发症。结果:术后1 d,两组视网膜局部微循环阻力指数(RI),房水SDF-1、VEGF水平,血清炎症因子IL-6、IL-8、IL-1β水平,黄斑中心凹视网膜厚度(CMT),最佳矫正视力(BCVA)均低于入院时,观察组低于对照组;两组视网膜局部微循环的舒张末期流速(EDV)、收缩期峰值流速(PSV)高于入院时,观察组高于对照组,差异有统计学意义(P<0.05)。两组并发症比较,差异无统计学意义(P>0.05)。结论:DR患者采用康柏西普眼用注射液联合PRP可促进视网膜局部微循环的改善,提高患者视力。

Objective: To investigate the effects of conbercept ophthalmic injection combined with panretinal photocoagulation(PRP) on local retinal microcirculation in patients with diabetic retinopathy(DR). Methods: A total of 82 DR patients were randomized into two groups, each with 41 cases. The control group received PRP treatment, while the observation group were treated with conbercept combined with PRP. The retinal microcirculation, levels of aqueous humor stromal cell-derived factor 1(SDF-1), vascular endothelial growth factor(VEGF), inflammatory factors, visual acuity and complications were compared between the two groups. Results: On the 1 st day after operation, the resistance index(RI) of local retinal microcirculation, aqueous humor SDF-1, VEGF levels, interleukin-6(IL-6), IL-8, IL-1β and central macular thickness(CMT), the best corrected visual acuity(BCVA) of both groups were lower than those on admission, and the observation group′s were lower than the control group′s;the end diastolic velocity(EDV) and peak systolic velocity(PSV) of the local retinal microcirculation in patients of both groups were higher than that on admission, the observation group′s was higher than that of the control group, the differences were statistically significant(P<0.05);and there was no significant difference in the incidence of complications between the two groups(P>0.05). Conclusion: For DR patients, conbercept ophthalmic injection combined with PRP can promote local retinal microcirculation, and improve patients′visual acuity.