摘要
新冠肺炎疫情已在全球大流行,对人类生命健康和社会经济造成了严重影响。随着SARS-CoV-2优势毒株在药物和抗体的压力下进化演变,变异毒株造成疫情复发并具有新特征,增加了疫情防控难度。接种疫苗是目前最有效的防控新冠肺炎疫情的策略之一,全球相继研发了灭活疫苗、亚单位疫苗、RNA疫苗和病毒载体疫苗等多类候选疫苗,部分疫苗已投入使用,并取得了良好效果。本文就SARS-CoV-2及其变异、疫苗开发平台和候选疫苗方面的研究进展进行综述。
COVID-19 has become a global pandemic, which has seriously affected human life, health and social economy. With the evolution of the dominant SARS-CoV-2 strain under the pressure of drugs and antibodies, the mutant strain has caused the recurrence of the epidemic and has new characteristics, increasing the difficulty of epidemic prevention and control. Vaccination is one of the most effective strategies to prevent and control COVID-19. Inactivated vaccines, subunit vaccines, RNA vaccines, viral vector vaccines and other candidate vaccines have been developed allover the world. Some vaccines have been put into use and achieved good results. In this paper, the research progress of SARS-CoV-2 and its variants, vaccine development platforms and candidate vaccines were briefly reviewed.
作者
黄垄琦
刘启亮
HUANG Longqi;LIU Qiliang(Key Laboratory of Biochemistry and Molecular Biology of Guangxi University,Guilin Medical University,Guilin 541199,China;Key Laboratory of Medical Biotechnology and Translational Medicine of Guangxi University,Guilin Medical University,Guilin 541199,China)
出处
《华夏医学》
CAS
2022年第5期172-178,共7页
Acta Medicinae Sinica
基金
国家自然科学基金(32160186)
广西大学生创新创业训练计划项目(202110601035)。
关键词
严重急性呼吸综合征冠状病毒2型
变异株
疫苗
候选疫苗
severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)
variant
vaccines
candidate vaccine
