奥卡西平在癫痫患儿中的临床疗效及对脑电参数的影响观察

Observation on the Clinical Efficacy of Oxcarbazepine in the Treatment of Children with Epilepsy and Influence for Electroencephalogram Parameters

目的:探究奥卡西平在癫痫患儿中的临床疗效及对脑电参数的影响。方法:将2019年12月-2021年12月福建省妇幼保健院神经内科收治的80例癫痫患儿按照随机数字表法分为对照组和观察组,各40例。对照组采用丙戊酸钠进行治疗,观察组则采用奥卡西平进行治疗。比较两组的癫痫控制率、治疗总有效率、不良反应发生率、治疗前后的发作频率和持续时间、脑电图参数及生存状态[中文版父母评价的儿童癫痫生活质量量表(PPRS-QOLCE)]。结果:观察组的癫痫控制率、治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组的发作频率和持续时间、脑电图参数及PPRS-QOLCE量表评分比较,差异无统计学意义(P>0.05);治疗3个月及6个月后,两组的发作频率和持续时间、脑电图参数及PPRS-QOLCE量表评分持续改善,且观察组优于对照组,差异均有统计学意义(P<0.05)。结论:奥卡西平在癫痫患儿中的应用效果较好,且可显著改善患儿的脑电参数,在癫痫患儿中的应用价值较高。

Objective:To investigate the application effect of Oxcarbazepine in the treatment of children with epilepsy and influence for electroencephalogram parameters.Method:A total of 80 children with epilepsy in the Department of Pediatrics of Fujian Maternal and Child Health Hospital from December 2019 to December 2021 were divided into control group and observation group by the random number table,40 cases in each group.The control group were treated with Sodium Valproate,the observation group were treated with Oxcarbazepine.Then the epilepsy control rate and total effective rate,adverse reactions rate,seizure frequency and duration,electroencephalogram parameters and survival state[Chinese version of the parent-proxy health-related quality of life measure for children with epilepy(PPRS-QOLCE)]before and after the treatment of two groups were compared.Result:The epilepsy control rate and total effective rate in observation group were significantly higher than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no significant differences between the two groups in seizure frequency and duration,electroencephalogram parameters and PPRS-QOLCE score(P>0.05).After 3 and 6 months of treatment,the attack frequency and duration,electroencephalogram parameters and PPRS-QOLCE scale scores in the two groups continued to improve,and the observation group were better than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Oxcarbazepine in the treatment of children with epilepsy is better,and it can significantly improve the electroencephalogram parameters of children,so its application value in the children with epilepsy is higher.