FIB、D-D、PLT对妊娠期高血压疾病患者下肢深静脉血栓的预测价值

Predictive Value of FIB,D-D,PLT on Lower Extremity Deep Vein Thrombosis in Patients with Hypertensive Disorders of Pregnancy

目的:分析纤维蛋白原(FIB)、D-二聚体(D-D)、血小板计数(PLT)对妊娠期高血压疾病患者下肢深静脉血栓的预测价值。方法:回顾性选取2021年1月-2022年1月沭阳县中医院分娩的68例妊娠期高血压疾病患者。所有患者进行FIB、D-D、PLT检测,并统计入院后2个月内下肢深静脉血栓发生情况,并进行分组。统计入院后2个月内患者下肢深静脉血栓发生率,并将其分为发生组及未发生组。比较两组患者FIB、D-D、PLT水平。分析FIB、D-D、PLT单独及联合检测对下肢深静脉血栓的预测价值。结果:入院后2个月内共有16例患者发生下肢深静脉血栓,左下肢深静脉血栓者7例,右下肢深静脉血栓者6例,双下肢深静脉血栓者3例,发生率为23.53%(16/68),纳入发生组;52例患者未发生下肢深静脉血栓,纳入未发生组。发生组患者FIB、D-D、PLT水平均高于未发生组患者,差异均有统计学意义(P<0.05)。FIB、D-D、PLT联合检测下肢深静脉血栓的敏感度、AUC均高于单独检测(Z=3.574、4.257、3.025,P<0.001)。结论:入院后下肢深静脉血栓发生的妊娠期高血压疾病患者FIB、D-D、PLT水平高,FIB、D-D、PLT联合检测预测价值高于单独检测,预测价值较高,值得推广。

Objective:To analyze the predictive value of fibrinogen(FIB),serum D-dimer(D-D)and platelet count(PLT)on lower extremity deep vein thrombosis in patients with hypertensive disorders of pregnancy.Method:From January 2021 to January 2022,68 patients with hypertensive disorders of pregnancy delivered in Shuyang Hospital of Traditional Chinese Medicine were selected.FIB,D-D and PLT were detected in all patients,and the occurence condition of lower extremity deep vein thrombosis within 2 months after admission was counted and they were grouped.The incidence of lower extremity deep vein thrombosis in patients within 2 months after admission was counted and they were divided into incidence group and non incidence group.The levels of FIB,D-D and PLT were compared between the two groups.The predictive value of FIB,D-D,PLT alone and combined detection for lower extremity deep vein thrombosis was analyzed.Result:Within 2 months after admission,16 patients had deep vein thrombosis of lower extremities,including 7 patients with deep vein thrombosis of left lower extremities,6 patients with deep vein thrombosis of right lower extremities,and 3 patients with deep vein thrombosis of both lower extremities,the incidence rate was 23.53%(16/68),and they were included in the incidence group;52 patients had no deep vein thrombosis of lower extremities and were included in the non incidence group.The levels of FIB,D-D and PLT in the incidence group were higher than those in the non incidence group,the differences were statistically significant(P<0.05).The sensitivity and AUC of combined detection of FIB,D-D and PLT for lower extremity deep vein thrombosis were higher than those of alone detection(Z=3.574,4.257,3.025,P<0.001).Conclusion:The levels of FIB,D-D and PLT in patients with hypertensive disorders of pregnancy with lower extremity deep vein thrombosis after admission are high.The predictive value of combined detection of FIB,D-D and PLT is higher than that of alone detection,and the predictive value is higher,which is worth of propularizing.