葛根姜黄虫藤饮治疗神经根型颈椎病临床观察

Clinical Observation of Gegen Jianghuang Chongteng Decoction on Cervical Spondylotic Radiculopathy

目的:探讨葛根姜黄虫藤饮治疗气滞血瘀证神经根型颈椎病的临床效果及对炎症因子表达的影响。方法:选择2018年1月-2021年10月收治于厦门大学附属中山医院的113例神经根型颈椎病患者,根据就诊顺序采用随机数字表法将其分为对照组(n=56)和研究组(n=57)。对照组予以塞来昔布治疗,研究组在对照组基础上予葛根姜黄虫藤饮加减,两组均连续治疗2周。比较两组治疗前后的疼痛程度(McGill问卷评分)、颈椎病临床评价量表(CASCS)评分及血清C反应蛋白(CRP)、白细胞介素-6(IL-6)水平,评估两组临床疗效。结果:研究组的总有效率为87.72%,明显高于对照组的71.43%(P<0.05)。治疗后两组VAS、PRI、PPI评分均较治疗前下降,研究组上述评分均低于对照组(P<0.05)。治疗后两组CASCS评分均较治疗前升高,研究组的症状、体征和社会适应能力评分均高于对照组(P<0.05)。治疗后,两组CRP、IL-6水平均较治疗前下降,研究组CRP、IL-6均低于对照组(P<0.05)。结论:葛根姜黄虫藤饮可缓解气滞血瘀证神经根型颈椎病的临床症状,降低炎症因子的表达。

Objective:To investigate the clinical effect of Gegen Jianghuang Chongteng Decoction in treating cervical spondylotic radiculopathy with Qi stagnation and blood stasis syndrome and its influence on the expression of inflammatory factors.Method:A total of 113 patients with cervical spondylotic radiculopathy who were admitted to Zhongshan Hospital Xiamen University from January 2018 to October 2021 were selected and divided into control group(n=56)and study group(n=57)by random number table according to the order of treatment.The control group was treated with Celecoxib,and the study group was treated with Gegen Jianghuang Chongteng Decoction on the basis of the control group,both groups were treated for 2 consecutive weeks.The pain degree(McGill questionnaire score),the clinical evaluation scale of cervical spondylosis(CASCS)score,and the levels of serum C-reactive protein(CRP)and interleukin-6(IL-6)were compared between the two groups before and after treatment,the clinical efficacy of the two groups was evaluated.Result:The total effective rate of the study group was 87.72%,which was significantly higher than 71.43%of the control group(P<0.05).After treatment,VAS,PRI and PPI scores of the two groups decreased compared with those before treatment,and those of the study group were lower than those of the control group(P<0.05).After treatment,the scores of CASCS in both groups were hi gher than those before treatment,and the scores of symptoms,signs and social adaptability in the study group were higher than those in the control group(P<0.05).After treatment,the levels of CRP and IL-6 in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).Conclusion:Gegen Jianghuang Chongteng Decoction can relieve the clinical symptoms of cervical spondylotic radiculopathy with Qi stagnation and blood stasis syndrome,and reduce the expression of inflammatory factors.