基于数据挖掘探讨魏玮教授治疗腹泻型肠易激综合征的用药规律

Exploration on medication rules of Professor Wei Wei in the treatment of diarrhea predominant irritable bowel syndrome based on data mining

目的基于数据挖掘探讨魏玮教授治疗腹泻型肠易激综合征(IBS-D)的用药规律。方法收集2016年1月至2021年1月于中国中医科学院望京医院魏教授门诊就诊的IBS-D患者病例,使用Excel 2019、SPSS 20.0、SPSS Modeler 18.0软件分析处方药物的频次、性味归经、强关联药物和核心组方。结果共收集处方237张,涉及中药91味,中药频次共计3014次,使用最多的药物为补虚药、消食药。药物使用频次前5位为太子参、肉豆蔻、补骨脂、炒谷芽、炒麦芽。药性以温为主;药味以辛、苦、甘为主;归经以脾、胃经为主。关联频次≥100次的药物组合有14组,聚类分析获得核心药物组合4组。结论魏教授治疗IBS-D多采用补虚药、消食药,治则以健脾温肾,和中益气,醒脾开胃为主。

Objective To explore the medication rules of Professor Wei Wei in treating diarrhea predominant irritable bowel syndrome(IBS-D)based on data mining.Methods The data of IBS-D patients treated by Professor Wei Wei in Wangjing Hospital of China Academy of Chinese Medical Sciences from January 2016 to January 2021 were collected.Excel 2019,SPSS 20.0 and SPSS Modeler 18.0 were used to analyze the frequency,nature,flavour and channel tropism of prescription drugs,strong related drugs and core components.Results Two hundred and thirty-seven prescriptions were collected,involving 91 kinds of traditional Chinese medicine,frequency of traditional Chinese medicine was 3014 times in total.The most frequently used drugs were tonifying deficiency drug and digestant drug.The top five drug use frequencies were Pseudostellariae Radix,Myristicae Semen,Psoraleae Fructus,Setariae Fructus Germinatus,Hordei Fructus Germinatus.The drug nature was mainly warm;the drug flavours were mainly pungent,bitter and sweet;spleen and stomach channels were the main channel tropism.Combination of drugs with correlation frequency more than 100 times was 14 groups.Four groups of core medicine combinations were obtained according to the results of cluster analysis.Conclusion Professor Wei Wei mostly uses tonifying dificiency drug and digestant drug in the treatment of IBS-D.The main treatment principle is to strengthen the spleen and warm the kidney,regulating stomach and benefiting qi,help the spleen and stomach transport.