组蛋白去乙酰化酶3——预防器官缺血/再灌注损伤的关键靶点

HDAC3——a key target for preventing organ ischemia-reperfusion injury

组蛋白去乙酰化酶3(histone deacetylase 3,HDAC3)在染色质重塑过程中发挥重要的作用,而染色质重塑反过来调节基因转录,因此,HDAC3通过表观遗传调控作用参与多种疾病的病理生理过程。器官缺血/再灌注损伤(ischemia-reperfusion injury,IRI)是导致多种疾病,如迟发性神经元坏死、不可逆性休克、心肌梗死、急性器官功能衰竭及器官移植排斥反应等疾病发生发展的病理生理学过程。该文就HDAC3的病理生理学功能及其在人体实质器官IRI发生发展中的作用进行综述,同时也探讨了HDAC3在IRI中的治疗价值。

Histone deacetylase 3(HDAC3)plays an important role in chromatin remodeling,which in turn regulates gene transcription,so HDAC3 is involved in the pathophysiology of various diseases through epigenetic regulation.Organ ischemia-reperfusion injury(IRI)is a pathophysiological process that leads to the development of a variety of diseases such as delayed neuronal necrosis,irreversible shock,myocardial infarction,acute organ failure and organ transplant rejection.In this paper we review the pathophysiological function of HDAC3 and its role in the development of IRI in human parenchymal organs,and also explore the therapeutic value of HDAC3 in IRI.