摘要
In order to increase the skin retention of HPR(Hydroxypinacone Retinoate),a novel high oil-contained HPR transfersome WL-HPR1130 was prepared.Conventional essence containing HPR was used as the control group,WL-HPR1130 essence was used as the experimental group,the skin retention of HPR were determined respectively.The anti-wrinkle efficacy of WL-HPR1130 essence was evaluated at the same time.The retention of HPR was 11.40μg/cm2 in the experimental group and 1.41μg/cm2 in the control group,which was 8.08 times higher than the control group.The wrinkles and fine lines were significantly reduced and smoothed after 2 and 4 weeks by experimental group sample.The average length,width and depth of wrinkles were decreased by 14.26%,18.31%,7.17%after 2 weeks,and were decreased by 29.39%,38.25%,8.60%after 4 weeks.The average length,width and depth of fine lines were decreased by 22.35%,12.60%,8.00%after 2 weeks,and were decreased by 27.10%,20.24%and 15.90%after 4 weeks,which has a significant visual changes.WLHPR1130,a novel high oil-contained HPR transfersome formulation,can significantly increase the retention of HPR in the skin.And the WL-HPR1130 essence have remarkable anti-wrinkle and smooth fine lines effects.
