高危型人乳头瘤病毒感染宫颈癌组织中N-myc下游调节基因1蛋白表达及其临床意义分析

Expression of N-myc downstream regulated 1 protein in high-risk human papilloma virus infected cervical cancer and its clinical significance

目的探讨高危型人乳头瘤病毒(HPV)感染宫颈癌组织中N-myc下游调节基因1(NDRG1)蛋白表达及其临床意义。方法选取50例高危型HPV感染宫颈癌患者作为宫颈癌组,同期50例高危型HPV感染宫颈上皮内瘤变(CIN)患者作为CIN组。对比两组组织中NDRG1蛋白表达差异,分析宫颈癌组织中NDRG1蛋白表达情况与临床特征的关系,并分析宫颈癌患者预后的影响因素。结果宫颈癌组患者宫颈癌组织中NDRG1蛋白阳性表达率高于CIN组患者,差异有统计学意义(P<0.05)。NDRG1蛋白阳性表达与NDRG1蛋白阴性表达高危型HPV感染宫颈癌患者国际妇产科联盟(FIGO)分期、宫旁侵犯情况、淋巴结转移情况比较,差异均有统计学意义(P<0.05)。NDRG1蛋白阴性表达高危型HPV感染宫颈癌患者生存情况优于NDRG1蛋白阳性表达患者,差异有统计学意义(P<0.05)。FIGO分期为Ⅲ期、合并宫旁侵犯、合并淋巴结转移、NDRG1蛋白阳性表达均是高危型HPV感染宫颈癌患者预后的独立危险因素(P<0.05)。结论组织中NDRG1蛋白阳性表达是高危型HPV感染宫颈癌患者病情严重、预后不良的重要影响因素。

Objective To investigate the expression of N-myc downstream regulated 1(NDRG1)protein in high-risk human papilloma virus(HPV)infected cervical cancer tissue and its clinical significance.Method A total of 50 highrisk HPV infected cervical cancer patients were selected as the cervical cancer group,and 50 high-risk HPV infected cervical intraepithelial neoplasia(CIN)patients were selected as the CIN group during the same period.The difference in NDRG1 protein expression in the two groups of tissue was compared.The relationship between NDRG1 protein expression and clinical features in cervical cancer tissue was analyzed.The prognosis factors in cervical cancer patients was also analyzed.Result The positive expression rate of NDRG1 in cervical cancer tissue of the cervical cancer group was higher than that of the CIN tissue,and the difference was statistically significant(P<0.05).There were significant differences in the International Federation of Gynecology and Obstetrics(FIGO)staging,parametrial invasion,and lymph node metastasis in patients with high-risk HPV infection with positive or negative NDRG1 expression(P<0.05).The survival of cervical cancer patients with high-risk HPV infection and NDRG1 negative was better than that of patients with positive expression of NDRG1,and the difference was statistically significant(P<0.05).FIGO stage III,combined with parametrial invasion,combined with lymph node metastasis,and positive expression of NDRG1 protein were all independent risk factors for the prognosis of cervical cancer patients with high-risk HPV infection(P<0.05).Conclusion The positive expression of NDRG1 protein in tissue is an important risk factor for severe disease and poor prognosis of cervical cancer patients with high-risk HPV.