单/同轴载SM药/微球支架的制备及性能研究

Preparation and performance of monaxial/coaxial scaffolds with SM drug-loaded/microspheres

为解决单轴载药/微球支架释药突释显著及力学性能较低等问题,达到病灶区长期稳定释放抗结核药物并修复重建骨缺损的目的,本研究采用3D同轴打印技术和冷冻干燥法分别制备了单/同轴载SM原药、载SF/SM微球、载GO/SF/SM微球支架,并对比分析各支架体外降解、力学和药物缓释性能,选出满足人体松质骨处应用要求的骨支架。结果表明,微球的加入加快了支架的降解,同轴结构延缓了支架中药物的释放,同轴载GO/SF/SM微球支架12周内总降解率最高为13.15%,最大抗压强度为5.87 MPa,弹性模量为61.28 MPa,累积释药率达75.1%,综合性能最优,且满足人体松质骨使用要求。

In order to solve the problems that monaxial drug-loaded/microsphere scaffolds release drugs rapidly and bear load weakly,monaxial/coaxial scaffolds with drug-loaded/microspheres were prepared by 3D coaxial-printing technology and freeze-drying method to release anti-tuberculosis drugs continuously for repairing defects of bone.In vitro degradation experiment,mechanical test and drug release experiment were used to choose scaffolds that met the application requirements of cancellous bone.The results showed that the use of microspheres speeded up the degradation of scaffolds,and the coaxial structure delayed the release of drugs in scaffolds.By comparison,the total degradation rate of GO/SF/SM coaxial scaffolds was 13.15%,the maximum compressive strength was 5.87 MPa and elastic modulus was 61.28 MPa.The sudden release phenomenon in the early stage of drug release was significantly reduced,the overall drug release was gentle,the drug release rate reached 71.5%within 12 weeks,the comprehensive performance was the best,and met the requirements of human cancellous bone.