醒脑静注射液联合安宫牛黄丸治疗脑出血临床研究

Clinical Study on Xingnaojing Injection Combined with Angong Niuhuang Pills for Cerebral Hemorrhage

目的:观察醒脑静注射液联合安宫牛黄丸治疗脑出血的临床疗效。方法:选取70例脑出血患者,采用随机数字表法分对照组和观察组各35例。对照组给予醒脑静注射液治疗,观察组在对照组基础上给予安宫牛黄丸治疗,2组均持续治疗1个月。比较2组临床疗效、不良反应发生率,以及治疗前后中医证候积分、氧化应激指标。结果:观察组总有效率94.29%,高于对照组74.29%(P<0.05)。治疗后,2组主症、次症积分及总分均较治疗前降低(P<0.05),观察组主症、次症积分及总分均低于对照组(P<0.05)。治疗后,2组总抗氧化能力(TAC)、超氧化物歧化酶(SOD)水平均较治疗前升高(P<0.05),丙二醛(MDA)水平均较治疗前降低(P<0.05);观察组TAC、SOD水平均高于对照组(P<0.05),MDA水平低于对照组(P<0.05)。观察组不良反应发生率8.57%,与对照组11.43%比较,差异无统计学意义(P>0.05)。结论:醒脑静注射液联合安宫牛黄丸治疗脑出血,可明显改善患者的临床症状,抗氧化应激效果理想,安全性高。

Objective: To observe the clinical effect of Xingnaojing Injection combined with Angong Niuhuang Pills on cerebral hemorrhage. Methods: A total of 70 patients with cerebral hemorrhage were selected and divided into the control group and the observation group according to the random number table method,with 35 cases in each group. The control group was treated with Xingnaojing Injection,and the observation group was additionally treated with Angong Niuhuang Pills based on the treatment of the control group. Both groups were treated for one month continuously. The clinical effects, incidence of adverse reactions, traditional Chinese medicine(TCM) syndrome scores and oxidative stress indexes before and after treatment were compared between the two groups. Results:The total effective rate was 94.29% in the observation group, higher than that of 74.29% in the control group(P<0.05). After treatment, the scores of primary symptoms and secondary symptoms as well as the total scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of total antioxidant capacity(TAC) and superoxide dismutase(SOD) in the two groups were increased when compared with those before treatment(P<0.05),and the levels of malondialdehyde(MDA) were decreased(P<0.05);the levels of TAC and SOD in the observation group were higher than those in the control group(P<0.05),and the level of MDA in the observation group was lower(P<0.05). The incidence of adverse reactions was8.57% in the observation group and 11.43% in the control group, there being no significant difference between the two groups(P>0.05). Conclusion:The therapy of Xingnaojing Injection combined with Angong Niuhuang Pills can significantly improve the clinical symptoms of patients with cerebral hemorrhage,with ideal effect of anti-oxidative stress and high safety.