复发缓解型多发性硬化患者的抑郁症状与疲劳及生活质量的相关性

Depression in patients with relapsing-remitting multiple sclerosis and its relationship with fatigue and quality of life

目的:探讨复发缓解型多发性硬化患者抑郁症状与疲劳及生活质量的相关性。方法:选取复发缓解型多发性硬化患者共80例,采用自编问卷收集患者人口学资料与疾病相关信息;采用贝克抑郁量表第2版中文版(BDI-Ⅱ)评估抑郁症状;采用疲劳影响量表修订版(MFIS)评估疲劳症状;采用健康状况调查问卷(SF-36)评估生活质量。结果:复发缓解型多发性硬化患者BDI-Ⅱ分为(10.43±6.74)分,其中,轻度抑郁11.3%(9/80),中度抑郁11.3%(9/80),重度抑郁1.3%(1/80)。多因素线性回归分析结果显示,BDI-Ⅱ评分与年龄(β=0.17,95%CI:0.01~0.33)和MFIS分(β=0.14,95%CI:0.06~0.22)正相关,与情感角色(β=-0.05,95%CI:-0.08~-0.01)和精神健康(β=-0.59,95%CI:-0.20~-0.04)负相关(P<0.05或P<0.01)。结论:复发缓解型多发性硬化患者抑郁症状的发生率较高,需要重点关注高龄、疲劳程度重及生活质量较差的患者。

Objective:To explore the associations between depression and perceived fatigue and the quality of life in patients with relapsing-remitting multiple sclerosis.Method:A total of 80 patients with relapsing-remitting multiple sclerosis were recruited.Data pertaining to demographic and disease-related characteristics were collected from the participants.Depressive symptoms were evaluated using the Chinese version of Beck Depression Inventory-II(BDI-II),fatigue was assessed using the Modified Fatigue Impact Scale(MFIS),and perceived health-related quality of life and health status were measured using the Short-Form-36 Health Survey(SF-36).Results:The score of BDI-Ⅱ in patients with relapsing-remitting multiple sclerosis was(10.43±6.74),including mild depression 11.3%(9/80),moderate depression 11.3(9/80) and severe depression 1.3%(1/80).Multivariate linear regression analysis showed that the score of BDI-Ⅱ was positively correlated with age(β=0.17,95%CI:0.01~0.33) and MFIS score(β=0.14,95%CI:0.06~0.22),and negatively correlated with role-emotional(β=-0.05,95%CI:-0.08~-0.01) and mental health(β=-0.59,95%CI:-0.20~-0.04;P<0.05 or P<0.01).Conclusion:Our study demonstrated high level of depression in patients with relapsing-remitting multiple sclerosis.Higher levels of depression were associated with older patients,higher fatigue levels and poor quality of life.