摘要
为满足人工食管支架对材料结构与力学性能的要求,以聚乳酸(PLA)和聚乳酸-羟基乙酸共聚物(PLGA)为原材料、圆柱形聚四氟乙烯为模板、氯化钠为致孔剂,制备了三维多孔生物可降解聚合物人工食管支架,并对食管支架的形貌、微观结构及其力学性能进行表征。结果表明:制备的PLA和PLGA人工食管支架具有三维多孔结构,经乙醇处理后,食管支架的长度、管径和孔隙率均有一定程度的降低。PLA和PLGA三维多孔食管支架的微观结构为无定型结构,乙醇处理在一定程度上提升了2种食管支架的结晶度。PLA和PLGA食管支架的断裂强度和缝合强力分别为(2.68±0.46)MPa、(3.68±0.98)N和(1.53±0.21)MPa、(2.21±0.65)N,乙醇处理后,2种食管支架的拉伸强度和缝合强力均有一定程度提升。2种食管支架的缝合强力均超过了食管支架移植时支架所能承受的缝合强力。
In order to meet the requirements of artificial esophageal scaffolds on material′s structure and mechanical properties,three-dimensional porous biodegradable polymer artificial esophageal scaffolds were prepared with biodegradable polylactic acid(PLA)and polylactic acid-glycolic acid copolymer(PLGA)as raw materials,cylindrical polytetrafluoroethylene as template and sodium chloride as porogen.Morphology,microstructure and mechanical properties were characterized.The results show that the PLA and PLGA artificial esophageal scaffolds have three-dimensional porous structure.After ethanol treatment,the length,diameter and porosity of the esophageal scaffolds decrease to a certain extent.Microstructure of PLA and PLGA three-dimensional porous esophageal scaffolds is amorphous.Ethanol treatment improves the crystallinity of the two esophageal scaffolds to a certain extent.The breaking strength and suture strength of the PLA and PLGA esophageal scaffolds are(2.68±0.46)MPa,(3.68±0.98)N and(1.53±0.21)MPa,(2.21±0.65)N,respectively.After ethanol treatment,the tensile strength and suture strength of these two esophageal scaffolds are improved to a certain extent.The suture strength of the two esophageal scaffolds exceeds the suture strength that the scaffolds could bear during esophageal scaffolds transplantation.
作者
王曙东
WANG Shudong(School of Textile and Clothing,Yancheng Polytechnic College,Yancheng,Jiangsu 224005,China;College of Textile and Clothing Engineering,Soochow University,Suzhou,Jiangsu 215002,China;Jiangsu Jinmaisui New Energy Technology Co.,Ltd.,Yancheng,Jiangsu 224000,China)
出处
《纺织学报》
EI
CAS
CSCD
北大核心
2022年第12期16-21,共6页
Journal of Textile Research
基金
江苏省自然科学基金面上项目(BK20201216)
江苏高校青蓝工程项目(苏教师〔2018〕12号,苏教师〔2019〕3号)。
关键词
人工食管支架
聚乳酸
聚乳酸-羟基乙酸共聚物
生物可降解
结构
力学性能
artificial esophageal scaffold
polylactic acid
polylactic acid-glycdic acid copolymer
biodegradability
structure
mechanical property