中药调节肠道菌群防治血脂异常的作用研究

Research Progress on Role of Chinese Medicine Regulating Intestinal Flora in Prevention and Treatment of Dyslipidemia

血脂异常是由于脂代谢异常所致的代谢性疾病,以TC、TG和LDL-C水平升高等为主要临床特征,长期血脂异常会增加其他多种疾病的发生风险。近年来已有研究证明,中药在肠道菌群作用下会使相关的代谢产物更容易被吸收,同时还能调整菌群的组成及数量,从而恢复肠道的稳态及维持血脂平衡,因此调节肠道菌群可能是延缓和防治血脂异常及并发症进程的有效措施。中医药防治血脂异常效果显著,毒副作用小、作用靶点广、多种疗效,具有较高的应用价值。本文从中药及其有效成分、复方制剂、中药协同有益菌等调节肠道菌群的角度,对其改善或缓解血脂异常的作用研究进展进行述评,为后续中医药开展预防及治疗血脂异常的研究提供有益的参考方向。

Dyslipidemia, a metabolic disease characterized by increased TC, TG and LDL-L, has positive correlation with the risks of other diseases. Abnormal lipid metabolism is the major causes of dyslipidemia. Increasing evidence has revealed that traditional Chinese medicines are metabolized or biotransformed by human intestinal, relavant metabolities can be absorbed more easily. Meanwhile, traditional Chinese medicines can also regulate the composition and quantity of the intestinal flora to restore the homeostasis of intestinal microecology and maintain lipid balance.Thus, a potential strategy of preventing or delaying the progress of dyslipidemia-related diseases and its complications is regulating gut microbiota. Traditional Chinese medicine is effective in preventing and treating dyslipidema, and has little side effects, multiple effects and a wide range of targets, which has high application value. This article reviews the research progress in the understanding of Chinese medicines, extracts, compound preparations, co-administration of Chinese medicines and probiotics to improve dyslipidemia by regulating gut microbiota. We also provide reference and recommendations for future research on the prevention and treatment of dyslipidemia.