噻托溴铵粉雾剂对慢性阻塞性肺疾病患者肺功能与炎性因子水平的影响观察

Observation on the effect of tiotropium bromide powder for inhalation on pulmonary function and inflammatory factors level in patients with chronic obstructive pulmonary disease

目的 探讨噻托溴铵粉雾剂对慢性阻塞性肺疾病患者肺功能与炎性因子水平的影响。方法 67例慢性阻塞性肺疾病患者,按照随机数字表法分为对照组(33例)和观察组(34例)。对照组接受常规治疗,观察组在对照组基础上接受噻托溴铵粉雾剂治疗。比较两组治疗效果以及治疗前后的肺功能指标及炎性因子水平。结果 治疗后,观察组治疗总有效率100.00%高于对照组75.76%,差异有统计学意义(P<0.05)。治疗后,观察组用力肺活量(FVC)水平为(3.02±0.31)L、第1秒用力呼气容积(FEV1)水平为(2.19±0.28)L、最大通气量实测值占预计值百分比(MVV%pred)水平为(71.88±6.03)%、第1秒用力呼气容积与用力肺活量占比(FEV1/FVC)水平为(68.93±5.43)%,均高于对照组的(2.54±0.23)L、(1.69±0.24)L、(55.09±5.65)%、(61.99±4.56)%,差异有统计学意义(P<0.05)。治疗后,观察组肿瘤坏死因子-α(TNF-α)水平为(1.28±0.17)μg/L、白细胞介素-6(IL-6)水平为(47.44±2.87)pg/ml、超敏C反应蛋白(hs-CRP)水平为(2.59±0.19)mg/L,均低于对照组的(1.99±0.19)μg/L、(54.46±2.99)pg/ml、(2.87±0.21)mg/L,差异有统计学意义(P<0.05)。结论 慢性阻塞性肺疾病患者接受噻托溴铵粉雾剂治疗效果显著,可显著改善患者肺功能,抑制炎性因子水平,临床应用价值显著。

Objective To discuss the effect of tiotropium bromide powder for inhalation on pulmonary function and inflammatory factors level in patients with chronic obstructive pulmonary disease.Methods A total of 67 patients with chronic obstructive pulmonary disease were divided into control group(33 cases) and observation group(34 cases) according to random numerical table.The control group received routine treatment,while the observation group received tiotropium bromide powder for inhalation on the basis of the control group.The therapeutic effect,pulmonary function index and inflammatory factor level before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was 100.00%,which was higher than 75.76% of the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had forced vital capacity(FVC) of(3.02±0.31) L,forced expiratory volume in one second(FEV1) of(2.19±0.28) L,the percentage of maximum ventilation volume to predicted value(MVV% pred) of(71.88±6.03)%,and FEV1/FVC of(68.93±5.43)%,which were higher than(2.54±0.23) L,(1.69±0.24) L,(55.09±5.65)% and(61.99±4.56)% in the control group,and the differences were statistically significant(P<0.05).After treatment,the observation group had tumor necrosis factor-α(TNF-α) of(1.28±0.17) μg/L,interleukin-6(IL-6) of(47.44±2.87) pg/ml,and high-sensitivity C-reactive protein(hs-CRP) of(2.59±0.19) mg/L,which were lower than(1.99±0.19) μg/L,(54.46±2.99) pg/ml,and(2.87±0.21) mg/L in the control group,and the differences were statistically significant(P<0.05).Conclusion Tiotropium bromide powder for inhalation has significant effect on patients with chronic obstructive pulmonary disease,which can significantly improve the pulmonary function and inhibit inflammatory factors level of patients,and the clinical application value is significant.