多巴丝肼片联合普拉克索治疗帕金森病的临床效果研究

Study on the clinical effect of levodopa and benserazide hydrochloride tablets combined with pramipexole in the treatment of Parkinson’s disease

目的 探讨多巴丝肼片联合普拉克索治疗帕金森病的临床疗效。方法 108例帕金森病患者,按照随机数字表法分为对照组和研究组,各54例。对照组应用多巴丝肼片治疗,研究组行多巴丝肼片+普拉克索治疗。比较两组治疗效果、不良反应发生率及用药前后韦氏综合评定量表(Webster)评分、帕金森病综合评定量表Ⅲ(UPDRSⅢ)评分。结果 研究组总有效率96.30%高于对照组的81.48%,差异有统计学意义(P<0.05)。治疗前,两组Webster评分、UPDRSⅢ评分比较,差异无统计学意义(P>0.05);用药2个月后,研究组Webster评分(8.84±1.22)分、UPDRSⅢ评分(20.22±1.07)分均低于对照组的(10.21±1.54)、(24.51±2.61)分,差异有统计学意义(P<0.05)。研究组不良反应发生率5.56%低于对照组的20.37%,差异有统计学意义(P<0.05)。结论 多巴丝肼片与普拉克索联合治疗帕金森病的效果显著,不仅能够提高患者生活质量,还能改善运动功能,安全性高,值得临床应用。

Objective To discuss the clinical efficacy of levodopa and benserazide hydrochloride tablets combined with pramipexole in the treatment of Parkinson’s disease.Methods A total of 108 patients with Parkinson’s disease were divided into control group and research group according to the random numerical table,with 54 cases in each group.The control group was treated with levodopa and benserazide hydrochloride tablets,and the research group was treated with levodopa and benserazide hydrochloride tablets + pramipexole.Both groups were compared in terms of therapeutic effect,incidence of adverse reactions,Webster score and unified Parkinson’s disease rating scale Ⅲ(UPDRS Ⅲ) score before and after medication.Results The total effective rate 96.30% in the research group was higher than 81.48% in the control group,and the difference was statistically significant(P0.05).After 2 months of medication,the Webster score(8.84±1.22) points and UPDRS Ⅲ score(20.22±1.07) points of the research group were lower than(10.21±1.54) and(24.51±2.61) points of the control group,and the differences were all statistically significant(P<0.05).The incidence of adverse reactions 5.56% in the research group was lower than 20.37% in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of levodopa and benserazide hydrochloride tablets and pramipexole is effective in treating Parkinson’s disease.It can not only improve the patients’ quality of life,but also improve their motor function with high safety,which is worthy of clinical application.