短时间内二次静脉团注碘对比剂对机体血液生化指标的影响

Effect of twice intravenous bolus injection of iodine contrast media in short time on body blood biochemical indices

目的观察短时间内二次静脉团注碘对比剂(ICM)对机体血液生化指标的影响,为设置CT增强检查后血生化常规检查的合理采血时间及结果分析提供参考依据。方法2020年11月至2021年5月招募健康志愿者30名,男女各15名,平均年龄(53.03±6.58)岁。选择Iopromide 370,在短时间内接受2个部位序贯检查,根据志愿者体重和检查部位确定ICM注射剂量和速率。分别采集注射ICM前,注射后1、3 h 90份血液样本,监测指标包括肝功能[乳酸脱氢酶、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转移酶(GGT)等]、肾功能[肌酐、尿素氮、肾小球滤过率估计值等]和电解质[钠离子(Na^(+))、钾离子(K^(+))、钙离子(Ca^(2+))、氯离子(Cl^(-))]。比较志愿者ICM注射前,注射后1、3 h上述指标的差异。结果与注射ICM前比较,注射ICM后1、3 h ALT、Ca^(2+)均明显升高,尿素氮、Na^(+)、Cl^(-)均明显降低,差异均有统计学意义(P<0.05)。不同时间点其余各指标比较,差异均无统计学意义(P>0.05)。结论健康人群短时间内二次静脉团注Iopromide 370后1、3 h部分血生化指标较注射前有变化,但均在参考范围内波动,结果可供临床参考。

Objective To observe the effect of twice intravenous bolus injection of iodine contrast media(ICM)in short time on body blood biochemical indices to provide reference for setting up reasonable blood collection time and results analysis of blood biochemical routine detection after CT enhancement examination.Methods Thirty healthy volunteers[mean age(53.03±6.58)years old,15 males and 15 females]were recruited from November 2020 to May 2021.Iopromide 370 was selected,two site sequential examinations were received in a short time.The injection dose and rate of ICM were determined according to the patient’s body weight and examination site.A total of 90 blood samples were collected before injection of ICM,at 1,3 h after injection of ICM.The monitoring indices included the liver function(LDH,AST,ALT,GGT,etc.),kidney function(Crea,Urea,eGFR,etc.)and electrolytes(Na^(+),K^(+),Ca^(2+),Cl^(-)).The differences of the above indicators before injection,at 1,3 h after ICM injection in the volunteers were compared.Results Compared with those before ICM injection,ALT and Ca^(2+)levels at 1 and 3 h after ICM injection were significantly increased,while Urea,Na^(+)and Cl^(-)levels were significantly decreased,and the differences were statistically significant(P<0.05).There was no statistical difference in the levels of other indices at different time points(P>0.05).Conclusion Some blood biochemical indices of healthy subjects after twice injection of Iopromide 370 are changed,but which all fluctuate within the reference scope and the results could provide reference for clinic.