扶正固本方辅助治疗重症肺炎的疗效观察及对患者炎症反应与免疫功能的影响

Effect of Fuzheng Gubenfang in adjuvant therapy of severe pneumonia and its influence on inflammatory response and immune function

目的:探讨扶正固本方辅助治疗重症肺炎的疗效及对患者炎症反应、免疫功能的影响。方法:选取150例重症肺炎患者,按照治疗方式不同分为对照组(n=75)和观察组(n=75)。对照组予以常规治疗措施,观察组在此基础上予以扶正固本方。比较两组患者APACHEⅡ评分、CPIS评分、撤离呼吸机时间、ICU病房住院时间、炎性因子水平、免疫功能、不良反应及28 d病死情况。结果:治疗后,两组患者APACHEⅡ、CPIS评分及CRP、PCT、IL-6及TNF-α水平均有所下降,CD3+及CD4+水平均有所升高,且观察组上述指标的变化幅度均高于对照组(P<0.05);观察组的呼吸机撤机时间、ICU病房住院时间、不良反应发生率及病死率均低于对照组相(P<0.05)。结论:采用扶正固本方联合西药治疗重症肺炎,有助于缓解临床症状,控制机体炎症反应,同时提高患者免疫功能。

Objective:To investigate the observation of the curative effect of Fuzheng Gubenfang in adjuvant therapy of severe pneumonia and its influence on inflammatory response and immune function.Methods:150 patients with severe pneumonia were divided into control group(n=75)and observation group(n=75)depending on the different therapy methods.Conventional therapy was used of the control group,and on this basis,Fuzheng Gubenfang was used of the observation group.The APACHE II score,CPIS score,weaning time from ventilator,ICU hospital stay,inflammatory factor levels,immune function,untoward effects and 28 d mortality were compared between the two groups.Results:The APACHE II,CPIS scores and CRP,PCT,IL-6,TNF-αlevels of the both groups after therapy were decreased,CD3^(+) and CD4^(+) levels were increased,and the changes degree of the above indicators of observation group were higher compared with the control group(P<0.05).The weaning time of the ventilator,ICU stay length,the occurrence of untoward effects and mortality of observation group were lower compared with the control group(P<0.05).Conclusion:The use of Fuzheng Gubenfang combined with western medicine in the therapy of patients with severe pneumonia was beneficial to relieve the clinical symptoms and control the inflammatory response of body,while improving the patient's immune function.