小儿支原体肺炎血清P-选择素水平与心肌损害的相关性分析

Correlation between serum P-selectin level and myocardial damage in children with mycoplasma pneumonia

目的:探讨小儿支原体肺炎血清P-选择素(PS)水平与心肌损害的相关性。方法:选取96例支原体肺炎患儿为研究对象,根据疾病进程分为心肌损害组(n=25)与无心肌损害组(n=75)。比较两组患儿性别、年龄、血清PS、心肌型肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、白细胞(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平及住院天数;受试者工作特征(ROC)曲线下面积(AUC)评价各指标对心肌损害发生的预测价值;Logistic回归分析影响心肌损害的因素;Pearson相关性分析各指标与心肌损害发生的关系。结果:96例患儿中出现心肌损害25例,发生率为26.0%。心肌损害组患儿血清PS、CK-MB、cTnI、CRP、PCT水平及住院天数高于无心肌损害组(P<0.05)。ROC曲线分析显示,PS、CK-MB、cTnI对心肌损害有有较高的预测诊断价值。回归分析显示,PS、PCT是支原体肺炎患儿发生心肌损害的独立影响因素(P<0.05)。相关性分析显示,患儿住院天数及血清PS水平与心肌损害的发生呈正相关(P<0.05)。结论:支原体肺炎患儿血清PS水平对心肌损害的发生有较高预测诊断价值,临床应加强其水平的监测。

Objective:To analyze the correlation between serum P-selectin(PS)level and myocardial damage in children with mycoplasma pneumonia.Methods:96 children with mycoplasma pneumonia were divided into myocardial damage group(n=25)and non-myocardial damage group(n=75)according to the disease process.The gender,age,serum levels of PS,creatine kinase-MB isoenzyme(CK-MB),cardiac troponin I(cTnI),white blood cell(WBC),C-reactive protein(CRP)and procalcitonin(PCT)and the length of hospital stay were compared between the two groups.The value of these indexes for diagnosis of myocardial damage was evaluated through the area under receiver operating characteristic(ROC)curve.The influencing factors of myocardial damage were analyzed by Logistic regression,Pearson correlation analysis was used to analyze the relationship between each index and myocardial damage.Results:Myocardial damage occurred in 25 of 96 children,with an incidence of 26.0%.The serum levels of PS,CK-MB,cTnI,CRP,PCT and length of hospital stay in myocardial damage group were higher than those in non-myocardial damage group(P<0.05).The results of ROC curve showed that PS,CK-MB and cTnI had high diagnostic value for myocardial damage.Logistic regression showed that PS and PCT were the independent influencing factors of myocardial damage in children with mycoplasma pneumonia(P<0.05).Pearson correlation analysis showed that the serum PS level of all children was significantly positively correlated with the length of hospital stay(P<0.05).Conclusion:Serum level of PS has high predictive value for the occurrence of myocardial damage in children with mycoplasma pneumonia,and its monitoring should be strengthened in clinical practice.