基于肠道菌群探讨中医学从脾论治痛风的科学内涵

Scientific Connotation of Treating Gout from Spleen in Chinese Medicine Based on Intestinal Flora

痛风是嘌呤代谢紊乱及尿酸代谢障碍性疾病,中医学对此病多从肾、脾、肝三脏论治,但现代研究从肝、脾、肾三脏论治痛风的研究较少,缺乏现代科学依据进行解释。随着国内外的探索,肠道菌群与痛风的关联早已成为研究热门。故而本文基于肠道菌群角度,探讨中医“脾”在痛风的作用,为痛风的论治提供分子生物学的靶向依据,拓宽临床诊治痛风的思路,以期为中医学从“脾”论治痛风提供现代科学依据。

Gout is a disorder of purine metabolism and uric acid metabolism. TCM treatments for gout is mainly based on treating Kidney, Spleen and Liver. However, there are few modern studies on treatments of Liver, Spleen and Kidney, which lacks modern scientific basis for its explanation. With the exploration at home and abroad increases, the association between intestinal flora and gout has become a hot research topic. Therefore, the role of Spleen in treating gout is discussed in this study based on intestinal flora, which provided molecular biological targeted basis for the treatment of gout and broadened the thinking of clinical diagnosis and treatment of gout. This study provided modern scientific basis for the treatment of gout from Spleen in TCM.