对比腹腔镜肝切除术与射频消融术对原发性肝癌患者肝功能、T淋巴细胞亚群水平的影响

The Influence Comparation of Laparoscopic Hepatectomy and Radiofrequency Ablation on Liver Function and T Lymphocyte Subsets in Patients with Primary Liver Cancer

目的:对比腹腔镜肝切除术与射频消融术对原发性肝癌患者肝功能、T淋巴细胞亚群水平的影响。方法:选取龙岩市第二医院2019年11月-2021年11月收治的64例原发性肝癌患者作为本次观察对象,其中2019年11月-2020年11月治疗的患者为参照组(n=32),实施腹腔镜肝切除术治疗;2020年12月-2021年11月治疗的患者为研究组(n=32),实施腹腔镜射频消融术治疗。对比两组手术相关指标、疼痛程度[视觉模拟评分法(VAS)评分]、肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)]、T淋巴细胞亚群。结果:研究组手术时间、住院时间均短于参照组,且术中出血量少于参照组(P<0.05);研究组患者术后12、48、72 h VAS评分均低于参照组(P<0.05);治疗后,两组AST、ALT水平均有所上升,但研究组AST、ALT水平均低于参照组(P<0.05);同时,治疗后两组患者CD3^(+)、CD4^(+)水平均有所降低,CD8^(+)水平提升(P<0.05),且研究组患者CD3^(+)、CD4^(+)水平均高于参照组,CD8^(+)水平低于参照组(P<0.05)。结论:对原发性肝癌患者实施腹腔镜射频消融术治疗,能够有效缩短手术治疗时间,减少出血量及减轻患者疼痛程度,并能降低对肝功能、免疫功能影响。

Objective:To compare the effects of laparoscopic hepatectomy and radiofrequency ablation on liver function and T lymphocyte subsets in patients with primary liver cancer Method:A total of 64 patients with primary liver cancer admitted to the Second Hospital of Longyan from November 2019 to November 2021 were selected as the observation subjects.Among them,patients treated from November 2019 to November 2020 were the reference group (n=32) and underwent laparoscopic hepatectomy.Patients treated between December 2020and November 2021 were the study group (n=32) who underwent laparoscopic radiofrequency ablation.Operation related indexes,pain degree[visual analogue scale (VAS) score],liver function indexes (AST and ALT),T lymphocyte subsets were compared between two groups.Result:Compared with the reference group,the patients in the study group had shorter operative time,shorter hospital stay and less intraoperative bleeding (P<0.05).The VAS scores of the study group at 12,48 and 72 h after operation were lower than those of the reference group (P<0.05).After treatment,the levels of AST and ALT in two groups were increased,but the levels of AST and ALT in the study group were lower than those in the reference group (P<0.05),and the levels of CD3and CD4in the two groups were decreased,while the levels of CD8in the two groups were increased (P<0.05),the levels of CD3and CD4in the study group were higher than those in the reference group,while the level of CD8in the study group was lower than that in the reference group (P<0.05).Conclusion:Laparoscoplc radiofrequency ablation therapy for patients with primary liver cancer can effectively shorten the operation time,reduce the amount of bleeding,relieve the pain,and reduce the influence on the liver function and immune function of the patients.