疏肝健脾法联合多烯磷脂酰胆碱对非酒精性脂肪肝病患者血脂水平及肝功能的影响

Effect of Liver-soothing and Spleen-strengthening Method Combined with Polyene Phosphatidylcholine on Serum Lipid Level and Liver Function in Patients with Nonalcoholic Fatty Liver Disease

目的:探讨疏肝健脾法联合多烯磷脂酰胆碱对非酒精性脂肪肝病(NAFLD)患者血脂水平及肝功能的影响。方法:选取2020年1月-2022年1月广州医科大学附属第四医院收治的97例NAFLD患者,用随机数字表法将患者分成对照组(n=49)和试验组(n=48)。对照组采用多烯磷脂酰胆碱治疗,试验组在对照组基础上给予疏肝健脾法治疗。比较两组疗效、血脂[甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)]水平及肝功能[谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)]水平。结果:与对照组比,试验组总有效率高,差异有统计学意义(P<0.05)。与治疗前比,两组治疗12周后TC、LDL-C、TG水平均下降,HDL水平均上升,且试验组TC、LDL-C、TG水平均低于对照组,HDL-C水平高于对照组,差异均有统计学意义(P<0.05)。与治疗前比,两组治疗12周后ALT、GGT、AST水平均下降,且试验组ALT、GGT、AST水平均较对照组低,差异均有统计学意义(P<0.05)。结论:疏肝健脾法联合多烯磷脂酰胆碱可有效调节NAFLD患者血脂,改善肝功能。

Objective: To investigate the effects of liver-soothing and spleen-strengthening method combined with Polyene Phosphatidylcholine on blood lipid level and liver function in patients with non-alcoholic fatty liver disease(NAFLD). Method: A total of 97 NAFLD patients admitted to the Fourth Affiliated Hospital of Guangzhou Medical University from January 2020 to January 2022 were selected, they were divided into control group(n=49) and experimental group(n=48) according to random number table method. The control group was treated with Polyene Phosphatidylcholine, and the experimental group was treated with liver-soothing and spleen-strengthening method on this basis. The curative effect, blood lipid [triglycerides(TG), high density lipoprotein cholesterol(HDL-C), total cholesterol(TC), and low density lipoprotein cholesterol(LDL-C)] level and liver function [alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamyl transpeptidase(GGT)] levels of the two groups were compared. Result: Compared with control group, the total effective rate in the experimental group was higher, the difference was statistically significant(P<0.05). Compared with before treatment, after 12 weeks of treatment, the levels of TC, LDL-C and TG in both groups were decreased, while the levels of HDL-C were increased, and the levels of TC, LDL-C and TG in the experimental group were lower than those in the control group, while the level of HDL-C in the experimental group was higher than that in the control group, the differences were statistically significant(P<0.05). Compared with before treatment, ALT, GGT and AST levels in both groups decreased after 12 weeks of treatment, and ALT, GGT and AST levels in experimental groups were lower than those in control group, the differences were statistically significant(P<0.05). Conclusion: Liver-soothing and spleenstrengthening method combined with Polyene Phosphatidylcholine can effectively regulate blood lipids and improve liver function in NAFLD patients.