血清Toll样受体、抗氧化能力指标及基质金属蛋白酶在急性脑梗死患者中的变化探究

Investigation on the Change of Serum Toll Like Receptors, Antioxidant Capacity Indexes and Matrix Metalloproteinase of Patients with Acute Cerebral Infarction

目的:探究血清Toll样受体、抗氧化能力指标及基质金属蛋白酶在急性脑梗死患者中的变化。方法:选取2020年3月-2021年11月武汉科技大学附属天佑医院收治的120例急性脑梗死患者,根据美国国立卫生研究院卒中量表(NIHSS)评分分为A组(重度组)、B组(中度组)及C组(轻度组),每组40例,选取同期的40例健康同龄者为D组。比较四组的血清Toll样受体[Toll样受体-2(TLR-2)及Toll样受体-4(TLR-4)]、抗氧化能力指标[总抗氧化能力(TAC)、超氧化物歧化酶(SOD)及过氧化氢酶(CAT)]、基质金属蛋白酶[基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-3(MMP-3)及基质金属蛋白酶-9(MMP-9)]表达水平,采用Spearman秩相关分析血清Toll样受体、抗氧化能力指标及基质金属蛋白酶指标与急性脑梗死严重程度的关系。结果:A组、B组及C组的血清Toll样受体及基质金属蛋白酶表达水平均高于D组,A组及B组均高于C组,A组均高于B组;A组、B组及C组的血清抗氧化能力指标表达水平均低于D组,A组及B组均低于C组,A组均低于B组,差异均有统计学意义(P<0.05)。Spearman分析显示,血清Toll样受体及基质金属蛋白酶指标与急性脑梗死的严重程度均呈正相关,血清抗氧化能力指标与急性脑梗死的严重程度呈负相关(P<0.05)。结论:急性脑梗死患者的血清Toll样受体、抗氧化能力指标及基质金属蛋白酶表达显著异常,且与急性脑梗死严重程度密切相关,在急性脑梗死患者中的检测价值较高。

Objective: To investigate the change of serum Toll like receptors, antioxidant capacity indexes and matrix metalloproteinase of patients with acute cerebral infarction. Method: A total of 120 patients with acute cerebral infarction in Tianyou Hospital Affiliated to Wuhan University of Science and Technology from March 2020to November 2021 were divided into group A(severe group), group B(moderate group) and group C(mild group)with 40 cases in each group according to national institutes of health stroke scale(NIHSS) scores, 40 healthy persons of the same ages were as the group D. The serum Toll like receptors [Toll like receptor-2(TLR-2) and Toll like receptor-4(TLR-4)], antioxidant capacity indexes [total antioxidant capacity(TAC), superoxide dismutase(SOD)and catalase(CAT)] and matrix metalloproteinase [matrix metalloproteinase-2(MMP-2), matrix metalloproteinase-3(MMP-3) and matrix metalloproteinase(MMP-9)] of four groups were compared, then the relationship between those serum Toll like receptors, antioxidant capacity indexes, matrix metalloproteinase and severity degree of acute cerebral infarction were analyzed with Spearman rank correlation analysis. Result: The serum Toll like receptors and matrix metalloproteinase of the group A, group B and group C were higher than those of the group D, those of the group A and group B were higher than those of the group C, those of the group A were higher than those of the group B;the serum antioxidant capacity indexes of the group A, group B and group C were lower than those of the group D, those of the group A and group B were lower than those of the group C, those of the group A were lower than those of the group B, the differences were statistically significant(P<0.05). The correlation analysis showed the serum Toll like receptors and matrix metalloproteinase were positively correlated with severity degree of acute cerebral infarction, the serum antioxidant capacity indexes were negatively correlated with severity degree of acute cerebral infarction(P<0.05). Conclusion: The expression of serum Toll like receptors, antioxidant capacity indexes and matrix metalloproteinase of patients with acute cerebral infarction are significantly abnormal,and they have close relationship with severity degree of acute cerebral infarction, so their detection value in the patients with acute cerebral infarction are high.