白血病患者血清IL-6、MCP-1、IL-22水平变化及临床意义

Changes and Clinical Significance of Serum IL-6,MCP-1 and IL-22 Levels in Patients with Leukemia

目的:探讨白血病患者血清白细胞介素-6(IL-6)、人巨噬细胞趋化蛋白-1(MCP-1)、白细胞介素-22(IL-22)水平变化及临床意义。方法:选取江西省人民医院2018年6月-2021年6月收治的67例白血病患者作为白血病组,另外选取同期接受体检的健康者96例作为健康组,比较两组血清IL-6、MCP-1、IL-22水平,分析IL-6、MCP-1、IL-22在不同类型白血病患者中的表达水平。结果:白血病组与健康组性别、年龄差异均无统计学意义(P>0.05);白血病组IL-6、MCP-1、IL-22水平均显著高于健康组(P<0.05);Pearson相关性分析得出,血清IL-6、MCP-1、IL-22水平呈现互为正相关(P<0.05);白血病患者中,急性白血病组血清中IL-6、MCP-1、IL-22水平均显著高于慢性白血病组(P<0.05),淋巴细胞白血病组血清中IL-6、IL-22水平均显著高于粒细胞白血病组(P<0.05),但两组MCP-1差异无统计学意义(P>0.05);不同疾病时期白血病患者中,血清IL-6、IL-22水平从高到低依次为复发白血病组、初诊白血病组、缓解白血病组患者,各组差异均有统计学意义(P<0.05),而初诊白血病组与复发白血病组血清中MCP-1水平均显著高于缓解白血病组(P<0.05)。结论:不同分化成熟程度和自然病程、细胞类型及疾病时期白血病患者血清中IL-6、MCP-1、IL-22水平存在差异,检测血清中IL-6、MCP-1、IL-22水平可能有助于评估白血病患者病情,进而为临床治疗提供参考。

Objective:To investigate the changes and clinical significance of serum interleukin-6(IL-6),human macrophage chemoattractant protein-1(MCP-1) and interleukin-22(IL-22) in patients with leukemia.Method:A total of 67 leukemia patients treated in Jiangxi Provincial People’s Hospital from June 2018 to June 2021 were selected as leukemia group,and 96 healthy subjects who underwent physical examination in the same period were selected as healthy group.The levels of serum IL-6,MCP-1 and IL-22 in the two groups were compared,and their expression levels in different types of leukemia patients were analyzed.Result:There were no significant differences in sex and age between the leukemia group and the healthy group(P>0.05),but the levels of IL-6,MCP-1 and IL-22 in the leukemia group were significantly higher than those in the healthy group(P<0.05).Pearson correlation analysis showed that serum levels of IL-6,MCP-1 and IL-22 were positively correlated with each other(P<0.05).In patients with leukemia,the serum levels of IL-6,MCP-1 and IL-22 in acute leukemia group were significantly higher than those in chronic leukemia group(P<0.05),and the levels of IL-6 and IL-22 in lymphocytic leukemia group were significantly higher than those in myelocytic leukemia group(P<0.05),but there was no significant difference in MCP-1 between the two groups(P>0.05).In patients with leukemia in different disease stages,the levels of serum IL-6 and IL-22 from high to low were in the order of recurrent leukemia group,newly diagnosed leukemia group and remission leukemia group,and there were significant differences among all groups(P<0.05).The serum MCP-1 level in newly diagnosed leukemia group and relapse leukemia group was significantly higher than that in remission leukemia group(P<0.05).Conclusion:There are differences in serum IL-6,MCP-1 and IL-22 levels in patients with leukemia of different degrees of differentiation maturity and natural courses of disease,cell classification and disease in different stages.Detection of serum IL-6,MCP-1 and IL-22 may help to evaluate the disease condition of patients with leukemia,and then provide reference for clinical treatment.