23G玻璃体切割术术毕联合康柏西普治疗增生型糖尿病视网膜病变玻璃体积血的效果观察

Efficacy of 23G Vitrectomy Completed Combined with Conbercept in the Treatment of Proliferative Diabetic Retinopathy Vitreous Hemorrhage

目的:探讨23G玻璃体切割术术毕联合康柏西普治疗增生型糖尿病视网膜病变(PDR)玻璃体积血(VH)的效果。方法:选择2019年11月-2021年11月新余市人民医院眼科收治的68例PDR合并VH患者,根据治疗方案的差异将患者分为观察组(35例)和对照组(33例)。所有患者均行23G玻璃体切割术,观察组同时联合玻璃体腔内注入康柏西普,对照组不注射。比较两组黄斑中心视网膜厚度(CRT)、最佳校正视力(BCVA)、术后VH复发率及并发症发生率。结果:术后1周,两组CRT水平比较,差异无统计学意义(P>0.05)。术后1、3、6个月,观察组CRT水平均低于对照组,差异均有统计学意义(P<0.05)。术后1周和术后1、3、6个月,观察组BCVA水平均低于对照组,差异均有统计学意义(P<0.05)。观察组患者术后并发症发生率为5.71%,低于对照组的24.24%,VH复发率为2.86%(1/35),低于对照组的18.18%(6/33),差异均有统计学意义(P<0.05)。结论:术毕康柏西普注射辅助23G玻璃体切割术治疗PDR合并VH能够有效改善CRT、BCVA水平,改善患者视力,降低术后并发症发生率及VH复发率。

Objective:To investigate the efficacy of 23G vitrectomy completed combined with Conbercept in the treatment of proliferative diabetic retinopathy(PDR)vitreous hemorrhage(VH).Method:A total of 68 PDR patients complicated with VH admitted to the Ophthalmology Department of Xinyu People’s Hospital from November 2019 to November 2021 were selected,they were divided into observation group(35 cases)and control group(33 cases)according to the difference of treatment plans.All patients underwent 23G vitrectomy,the observation group was combined with intravitreal injection of Conbercept,while the control group was not injected.The central retinal thickness(CRT),best corrected visual acuity(BCVA),postoperative VH recurrence rate and complication rate were compared between the two groups.Result:1 week after operation,there was no significant difference in CRT levels between the two groups(P>0.05).At 1 month and 3,6 months after operation,CRT levels in observation group were lower than those in the control group,the differences were statistically significant(P<0.05).BCVA levels in the observation group were lower than those in the control group at 1 week,1 month and 3,6 months after operation,the differences were statistically significant(P<0.05).The incidence of postoperative complications in the observation group was 5.71%,which was lower than 24.24%in the control group,and the recurrence rate of VH in the observation group was 2.86%(1/35),which was lower than 18.18%(6/33)in the control group,the differences were statistically significant(P<0.05).Conclusion:Conbercept Injection assisted 23G vitrectomy in the treatment of PDR complicated with VH can effectively improve the levels of CRT and BCVA,improve the vision of patients,and reduce the incidence of postoperative complications and the recurrence rate of VH.