摘要
目的探究复方丹参滴丸对急性高原病作用机制。方法采用低压低氧舱,模拟海拔5000 m缺氧24 h,建立急性高原病大鼠模型。SD大鼠随机分为对照组、模型组、阳性药组和实验组。阳性药组灌胃30 mg·kg^(-1)乙酰唑胺、实验组灌胃给予72.9 mg·kg^(-1)复方丹参滴丸,对照组与模型组灌胃等体积蒸馏水,每日一次,连续给药7天,测定血气、生化指标等。结果对照组、模型组和实验组血氧饱和度分别为(98.97±3.52)%,(81.84±3.11)%,(96.53±3.99)%;肌酸激酶同工酶B含量分别为(328.1±148.7),(590.2±251.3)和(342.6±136.1)U·L^(-1);血糖分别为(7.9±1.4),(32.1±4.0)和(9.4±2.0)mmol·L^(-1)。上述指标,模型组与对照组相比,或实验组与模型相比,差异均有统计学意义(均P<0.05)。结论复方丹参滴丸可通过提高血氧饱和度,降低心肌酶,恢复代谢水平等起到促进大鼠高原习服的作用。
Objective To investigate the potential mechanism of compound Danshen dripping pills(CDDP)in protecting acute mountain sickness.Methods Acute mountain sickness rat model was established by decompression chamber for 24 h at 5000 m altitudes.Rats were randomly divided into four groups:control group,model group,positive group and experimental group.The positive group was given 30 mg·kg^(-1) acetazolamide by gavage,the experimental group was given 72.9 mg·kg^(-1) CDDP by gavage,and the control group and model group were given the same volume of distilled water by gavage,once a day for 7 days.The blood gas and biochemical indexes were measured.Results Blood oxygen saturation in control group,model group,and experimental group were(98.97±3.52)%,(81.84±3.11)%,(96.53±3.99)%.The content of creatine kinase myocardial band in three groups were(328.1±148.7),(590.2±251.3),(342.6±136.1)U·L^(-1).Blood glucose of three groups were(7.9±1.4),(32.1±4.0),(9.4±2.0)mmol·L^(-1).Compared between with model group and control group,or experimental group and model group,the differences of the factors were statistically significant(all P<0.05).Conclusion CDDP promote high altitude acclimatization of rat by improving blood oxygen saturation,reduce myocardial enzymes and restore metabolic level.
作者
闫佳怡
阮盼盼
张卓
葛运炫
高敬
谭红玲
肖成荣
高全胜
高月
YAN Jia-yi;RUAN Pan-pan;ZHANG Zhuo;GE Yuan-xuan;GAO Jing;TAN Hong-ling;XIAO Cheng-rong;GAO Quan-sheng;GAO Yue(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 511400,Guangdong Province,China;Beijing Institute of Radiation Medicine,Academy of Military Sciences,Beijing 100850,China;School of Life Science,Heibei University,Baoding 071000,Heibei Province,China;College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124,China;School of Pharmacy,Henan University,Kaifeng 475004,Henan Province,China;Institute of Environmental Medicine and Occupational Medicine,Academy of Military Sciences,Tianjin 300050,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2022年第22期2736-2739,共5页
The Chinese Journal of Clinical Pharmacology
基金
国家重点研发计划基金资助项目(2019YFC1604900)。
关键词
复方丹参滴丸
急性高原病
习服
心肌酶
代谢水平
compound Danshen dripping pills
acute mountain sickness
acclimatization
myocardial enzymes
metabolic level