噻托溴铵与沙美特罗替卡松在慢阻肺急性加重期治疗中的应用

Application of tiotropium bromide and salmeterol ticasone in the treatment of acute exacerbation of COPD

目的:对慢阻肺急性加重期患者采用噻托溴铵与沙美特罗替卡松治疗的效果予以探究。方法:选择本院在2020年1月至2021年2月收治的慢阻肺急性加重期患者92例纳入研究,根据盲选方式予以分组处理,甲组和乙组各有46例。甲组接受噻托溴铵治疗,乙组在这个基础上接受沙美特罗替卡松治疗。对比两组的疗效。结果:乙组的总有效率明显高于甲组,差异显著(P<0.05);乙组的第1秒用力呼气容积、用力肺活量明显高于甲组,差异显著(P<0.05);乙组的白细胞介素-6、肿瘤坏死因子、C反应蛋白等水平均明显低于甲组,差异显著(P<0.05)。结论:在慢阻肺急性加重期的治疗中,采用噻托溴铵与沙美特罗替卡松效果确切,可以有效改善患者的肺功能,并且降低其炎症因子水平。

Objective:To investigate the effect of tiotropium bromide and salmeterol ticasone in the treatment of patients with acute exacerbation of COPD.Methods:A total of 92 patients with acute exacerbation of COPD admitted to our hospital from January 2020 to February 2021 were included in this study.According to the blind selection method,they were divided into groups,with 46 patients in group A and group B.Group A received tiotropium bromide treatment,and group B received salmeterol ticasone treatment on this basis.The efficacy of the two groups was compared.Results:The total effective rate of group B was significantly higher than that of group A(P<0.05).The forced expiratory volume and forced vital capacity in 1 second in group B were significantly higher than those in group A(P<0.05).The levels of interleukin-6,tumor necrosis factor-αand C-reactive protein in group B were significantly lower than those in group A(P<0.05).Conclusion:In the treatment of acute exacerbation of COPD,tiotropium bromide and salmeterol ticasone can effectively improve the lung function of patients and reduce the level of inflammatory factors.