基于PDX模型进行癌症诊疗的进展

PDX Model-Aided Cancer Disgnosis and Treatment

肿瘤异质性是当前癌症研究中不可忽视的重要因素,精准医学为此提供了新的解决方法。随着多组学、基因组学、转录组学、代谢组学等信息统计及数据分析技术的发展,特别是直接进行原代肿瘤移植的人源肿瘤组织异种移植模型(Patient-derived xenograft,PDX)被广泛应用,为肿瘤患者的精准治疗奠定了基础。文章综述了PDX相关的进展,以及目前主要的PDX数据库资源共享平台,希望可以为肿瘤研究提供参考。

Tumor heterogeneity is the main abstacle in current cancer research and precision medicine provides a new solution for cancer treatment.Technique development in information statistics and data analysis in multiomics,e.g.genomics,transcriptome and metabonomics,together with the widely used patient-derived xenograft(PDX),laid the foundation for the accurate treatment of tumor patients.This paper reviews the progress of PDX model related research and the currently used major PDX database platforms,hoping to provide a reference for tumor research.