痛风与肠道菌群相关性的研究进展

Progress in research on the correlation between gout and intestinal flora

痛风是一种嘌呤代谢紊乱导致的炎症性疾病,表现为尿酸升高、阵发性关节肿痛、痛风结石形成和关节畸形等,严重影响患者的工作及生活质量。随着生活方式的改变,痛风的患病率不断升高。嘌呤代谢障碍和炎症通路异常在痛风的发病机制中起主要作用。研究表明痛风会引起肠道菌群的改变,肠道菌群不仅能够影响嘌呤代谢或调节炎症,还能够影响药物对痛风的治疗效果。因此本综述从肠道菌群调节嘌呤代谢、炎症反应及药物作用等方面,分析肠道菌群在痛风发病及治疗中的作用及功能,有助于阐明痛风与肠道菌群的相关性,为更好地诊治痛风提供新思路。

Gout is an inflammatory disease caused by purine metabolism disorder,characterized by increased uric acid,paroxysmal joint swelling and pain,gout stone formation,and joint deformity,which seriously affects the quality of life and work of patients.With the change of lifestyle,its prevalence rate is increasing rapidly.Purine metabolic disorders and abnormal inflammatory pathways play an important role in the pathogenesis of gout.Studies have shown that gout can cause changes in the intestinal microbiome.At the same time,intestinal flora can not only affect purine metabolism or regulate inflammation,but also affect the therapeutic effect of drugs on gout.Therefore,this review analyzes the role and function of intestinal flora in the pathogenesis and treatment of gout from the aspects of regulation of purine metabolism,inflammatory reaction and drug effect,with the purpose of clarifying the correlation between gout and intestinal flora,and providing new ideas for better diagnosis and treatment of gout.