益生菌对儿童重症肺炎合并腹泻的疗效

The clinical effect of probiotics on severe pneumonia complicated with gastrointestinal dysfunction in children

目的观察益生菌对儿童重症肺炎合并腹泻的临床疗效,为该类患者的治疗提供参考。方法选取2018年8月至2020年8月武清区人民医院收治的120例重症肺炎合并腹泻患儿为研究对象,按随机数字表法分为对照组和观察组,各60例。所有患儿均给予抗感染、对症支持等肺炎标准治疗,观察组患儿在对照组治疗的基础上加用益生菌,比较两组患儿腹泻持续时间、住院时间、治疗效果以及炎症因子的变化情况。结果观察组患儿治疗后腹泻持续时间及平均住院时间分别为(3.23±1.18)d、(10.33±2.86)d,均显著低于对照组的(6.57±1.13)d、(14.17±2.61)d。观察组、对照组患儿的治疗有效率分别为95.00%、75.00%,其中观察组显著高于对照组(χ^(2)=7.908,P=0.005)。治疗前两组患儿白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平差异均无统计学意义(均P>0.05)。治疗72 h后两组患儿IL-6和TNF-α水平均有明显改善,其中观察组IL-6[(18.93±4.15)ng/L]、TNF-α[(29.19±4.10)ng/L]水平均显著低于对照组[(33.02±6.38)ng/L、TNF-α(46.18±6.14)ng/L],差异有统计学意义(均P<0.05)。结论益生菌可降低重症肺炎合并腹泻患儿的腹泻持续时间,改善胃肠功能,同时能有效降低炎症因子水平,减轻炎症反应,缩短住院时间,且安全性高,值得临床推广应用。

Objective To observe the clinical effect of probiotics on severe pneumonia complicated with gastrointestinal dysfunction in children,providing a reference for the treatment.Methods From August 2018 to August 2020,120 children with severe pneumonia and gastrointestinal dysfunction were enrolled and divided into control group(60 cases)or observation group(60 cases).All the children were given standard treatment for pneumonia,such as anti-infection and symptomatic treatment.The observation group was additionally treated with probiotics.The duration of diarrhea,duration of hospitalization,therapeutic effect and the change of inflammatory factors were compared between the two groups.Results The duration of diarrhea and average length of stay were(3.23±1.18)days and(10.33±2.86)days respectively in observation group,significantly shorter than the(6.57±1.13)days and(14.17±2.61)days respectively in the control group(all P<0.05).The efficiency rate was 95.00%in the observation group vs 75.00%in the control group,with significant difference(χ^(2)=7.908,P=0.005).There were no significant differences in the levels of interleukin 6(IL-6)and tumor necrosis factorsα(TNF-α)between the two groups before treatment(all P>0.05).At 72 hours of treatment,the levels of IL-6 and TNF-A in the two groups significantly improved(all P<0.05).The levels of IL-6[(18.93±4.15)ng/L]and TNF-α[(29.19±4.10)ng/L]in the observation group were significantly lower than those in the control group[(33.02±6.38)ng/L,(46.18±6.14)ng/L]respectively.Conclusion Probiotics can reduce the duration of diarrhea and improve gastrointestinal dysfunction in children with gastrointestinal dysfunction and severe pneumonia,while improve gastrointestinal dysfunction,reduce the levels of inflammatory factors and inflammatory reaction,and shorten the length of stay,with high safety.