肠道微生物-短链脂肪酸轴与肥胖抑郁共病机制的研究进展

Progress in intestinal microbiota-short-chain fatty acid axis in mechanism of comorbid obesity and depression

肥胖和抑郁在全球范围内的患病率显著增长并已成为国内外重大公共卫生挑战[1]。近年来研究发现,肠道微生物-短链脂肪酸(short-chain fatty acids,SCFAs)轴参与了肥胖和抑郁的发生发展,是联系代谢与神经系统的枢纽[2]。本文总结了肥胖与抑郁共病的流行病学证据,指出二者之间存在复杂的双向联系,并从微生物-SCFAs轴的角度探索二者之间的共病机制,指出SCFAs的转运途径与作用靶点.

Obesity and depression are common conditions with major public health implications,and both of them show changes in intestinal microbiota.Short-chain fatty acids(SCFAs)are a category of metabolites of intestinal microbiota,which play an important role in regulating barrier immunological function and intestinal endocrine,and stimulating vague nerve.The present review specifically focuses on the comorbidity of obesity and depression from the perspective of intestinal microbiota-SCFA axis,in order to provide new ideas for clinical research.