肝细胞癌中表观遗传改变对免疫治疗的影响

Effects of Epigenetic Changes on Immunotherapy in Hepatocellular Carcinoma

肝细胞癌是最常见的恶性肿瘤之一,早期诊断困难,致死率高,相对于其他恶性肿瘤而言欠缺有效的治疗方法。近年来,表观遗传机制被广泛研究,与基因突变不同,表观遗传改变是动态的、可靶向修正的,且表观遗传失调对肿瘤免疫也产生影响。靶向修正表观遗传能够改善肿瘤免疫,增强免疫治疗效果,为探索新型联合治疗带来希望。全文主要讨论肝细胞癌发生发展过程中表观遗传的主要变化以及表观遗传对肿瘤免疫的影响,探索联合靶向表观遗传和免疫治疗新疗法。

Hepatocellular carcinoma(HCC)is one of the most common malignant tumors.It is dif-ficult to diagnose at the early stage and has a high mortality rate and lack of effective treatment methods compared with other malignant tumors.In recent years,epigenetic mechanisms have been extensively studied.Unlike gene mutations,epigenetic changes are dynamic and targetable,and epigenetic dysregulation also affects tumor immunity.Targeted modification of epigenetics can improve tumor immunity and enhance the effects of immunotherapy,bringing hope for the explo-ration of new combination therapies.This article reviews the main changes of epigenetics during the occurrence and development of HCC and the impact of epigenetics on tumor immunity,and explores new therapies that combine targeting epigenetics and immunotherapy.