2013-2018年江苏省江阴市结直肠癌发病趋势与生存分析

Incidence Trends and Survival of Colorectal Cancer in Jiangyin City of Jiangsu Province from 2013 to 2018

[目的]分析2013-2018年江苏省江阴市居民结直肠癌的发病趋势与生存情况。[方法]收集2013年1月1日-2018年12月31日江阴市肿瘤登记处登记的新发结直肠癌患者发病和随访资料,随访截止日期为2021年12月31日,计算结直肠癌的分性别粗发病率、中标率、0~74岁累积率、年度变化百分比(APC)及5年观察生存率(OSR)等指标。[结果] 2013-2018年江阴市登记的结直肠癌新发病例合计3 138例,占全部恶性肿瘤的11.56%,平均粗发病率为42.24/10万,中标率为21.50/10万,其中男性平均粗发病率和中标率分别为50.97/10万、26.78/10万,女性平均粗发病率和中标率分别为33.60/10万、16.52/10万,男性平均粗发病率高于女性。结直肠癌发病率随着年龄的增长逐渐上升,45岁后上升速度加快,75~岁年龄组达到高峰(202.38/10万),中位发病年龄为66.00岁。2013-2018年期间结直肠癌的粗发病率和中标率均呈上升趋势,APC分别为8.09%(95%CI:5.44%~10.77%,P<0.05)、6.16%(95%CI:4.18%~8.18%,P<0.05)。2013-2018年结直肠癌的5年OSR为53.75%,其中男性为53.80%、女性为53.68%,男女之间差异无统计学意义(χ^(2)=0.547,P=0.460)。不同年龄组之间比较,结直肠癌5年生存率差异有统计学意义(χ^(2)=311.778,P<0.05)。[结论]江阴市结直肠癌发病率总体呈上升趋势,且男性高于女性,5年生存率总体不高,应继续加强结直肠癌防治工作和持续推进结直肠癌的早筛早诊工作。

[Purpose] To analyze the incidence trend and survival of colorectal cancer in Jiangyin City of Jiangsu Province from 2013 to 2018.[Methods] The incidence and follow-up data of newly diagnosed colorectal cancer patients in Jiangyin Cancer Registry from January 2013 to December2018 were collected. The patients were followed up till December 31, 2021. The crude incidence rate, age-standardized rate, cumulative rate of 0~74 years old, annual percentage change(APC) of incidence and 5-year observed survival rate(OSR) of colorectal cancer by gender were calculated.[Results] There were 3 138 new cases of colorectal cancer registered in Jiangyin City from 2013to 2018, accounting for 11.56% of all malignant tumors. The average crude incidence rate was42.24/10^(5), and the age-standardized incidence rate by 2000’s Chinese standard population(ASRC)was 21.50/10^(5). The average crude incidence rate and ASRC of males were 50.97/10^(5)and 26.78/10^(5),respectively;and those of females were 33.60/10^(5)and 16.52/10^(5), respectively. The average crude incidence rate of males was significantly higher than that of females. The incidence of colorectal cancer was gradually increased with age, and accelerated after 45 years old, reaching a peak in the 75~ age group(202.38/10^(5)), and the median onset age was 66.00 years old. Both the crude incidence and ASRC of colorectal cancer showed upward trends from 2013 to 2018, and the APC were 8.09%(95%CI:5.44%~10.77%, P<0.05) and 6.16%(95%CI:4.18%~8.18%, P <0.05), respectively. The average 5-year OSR of colorectal cancer from 2013 to 2018 was 53.75%, with53.80% in male and 53.68% in female(χ^(2)=0.547, P=0.460). The 5-year OSR of colorectal cancer was significantly different among different age groups(χ^(2)=311.778, P<0.05). [Conclusion] The incidence of colorectal cancer in Jiangyin City showed an upward trend generally from 2013 to2018, and the incidence of males was higher than that of females. The 5-year OSR was relatively low. The prevention and treatment of colorectal cancer should be strengthened and the early screening and early diagnosis of colorectal cancer should be further promoted.