MDM4 rs4245739基因多态性与乳腺癌易感性的meta分析

MDM4 rs4245739 gene polymorphism and breast cancer susceptibility:A meta-analysis

目的探讨MDM4 rs4245739基因多态性与乳腺癌易感性之间的相关性。方法在PubMed、EMBASE、Cochrane Library、中国知识基础设施数据库和万方电子数据库中检索MDM4 rs4245739基因多态性与乳腺癌易感性的相关文献。用比值比和95%置信区间来评估相关性的强度。采用Begg's漏斗图和Egger's线性回归检验来评价发表偏倚。结果本研究共纳入6项研究,包括9814名乳腺癌患者和45202名健康对照者。MDM4 rs4245739在等位基因模型(C vs A:OR=0.84,95%CI:0.67-1.05,P=0.118)、显性基因模型(AC+CC vs AA:OR=0.86,95%CI:0.67-1.11,P=0.245)、隐性基因模型(AC+AA vs CC:OR=0.90,95%CI:0.61-1.32,P=0.585)、杂合子模型(AC vs AA:OR=0.88,95%CI:0.69-1.12,P=0.305)、纯合子模型(CC vs AA:OR=0.90,95%CI:0.59-1.39,P=0.649)中均提示其与乳腺癌易感性无相关性。同时,GEPIA数据库亦证实MDM4的表达水平与乳腺癌的肿瘤分期及预后无关。结论MDM4 rs4245739基因多态性和MDM4的表达水平与乳腺癌患者的易感性和预后均无关。

Objective To explore associations between MDM4 rs4245739 gene polymorphism and breast cancer susceptibility.Methods The papers related to polymorphisms of MDM4 rs4245739 and breast cancer susceptibility were searched in PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure and Wanfang electronic database.Odds ratios(ORs)and 95%confidence intervals(CIs)were adopted to assess the strength of associations.Publication bias was evaluated by Begg's funnel plot and Egger's linear regression test.Results A total of 6 studies involving 9814 breast cancer patients and 45202 healthy individuals were included in the present study.MDM4 rs4245739 in the allelic(C vs A:OR=0.84,95%CI:0.67-1.05,P=0.118),dominant(AC+CC vs AA:OR=0.86,95%CI:0.67-1.11,P=0.245),recessive(AC+AA vs CC:OR=0.90,95%CI:0.61-1.32,P=0.585),heterozygous(AC vs AA:OR=0.88,95%CI:0.69-1.12,P=0.305),homozygous(CC vs AA:OR=0.90,95%CI:0.59-1.39,P=0.649)genetic models show no association with the susceptibility to breast cancer.Moreover,GEPIA data confirmed that the expression level of MDM4 was not associated with the tumor staging and prognosis of breast cancer.Conclusion Neither MDM4 rs4245739 gene polymorphism nor MDM4 expression level is associated with the susceptibility and prognosis in breast cancer patients.