A型肉毒素治疗唾液腺非肿瘤性疾病研究进展

Progress of botulinum toxin type A in the treatment of non-neoplastic salivary gland disease

A型肉毒毒素(botulinum toxin A,BTX-A)是一种神经毒性蛋白,可抑制乙酰胆碱释放,从而阻断胆碱能受体的信号传导。BTX-A注射治疗已被广泛用于多个领域。近年来,BTX-A的应用价值及适应证不断被发掘与拓展,越来越多的研究关注其在唾液腺相关疾病的治疗应用,如用于治疗流涎症、涎瘘、囊肿等。本文综述了近年来国内外BTX-A用于治疗包括各类唾液腺非肿瘤疾病的相关文献,对治疗用量、注射方法、治疗效果等进行总结与探讨,以期为国内推广应用BTX-A局部注射治疗流涎症、涎瘘、慢性阻塞性腮腺炎提供参考与指导。

Botulinum toxin A(BTX-A)is a neurotoxic protein that inhibits the release of acetylcholine and blocks cholinergic receptor signaling.BTX-A therapy has been widely used in many fields.In recent years,the application value and indications of BTX-A have been continuously explored and expanded,and more and more studies have focused on its application in the treatment of salivary gland-related diseases,such as sialorrhea,salivary fistula,salivary gland cyst,Frey’s syndrome et al.In this paper,the literature on the use of BTX-A in the treatment of non-neoplastic salivary gland diseases including chronic obstructive parotitis in recent years was reviewed,and the treatment dosage,injection method and treatment effect were summarized and discussed,in order to provide reference and guidance for the clinical applica-tion in the treatment of chronic obstructive parotitis,sialorrhea and salivary fistula.