摘要
输血相关性急性肺损伤(TRALI)是由输血引起的呼吸窘迫和急性肺损伤,是在输血后6小时内导致患者死亡的主要原因之一,其病死率为5%-10%。TRALI的病理机制分为抗体介导和非抗体介导两种,对于其发病机理“二次打击”模型的研究也得到了越来越多的认可。但目前针对TRALI的治疗还没有明确的方法。本文对TRALI的发病机制及防治措施进行一系列阐述。
Transfusion-related acute lung injury(TRALI)is blood transfusion caused respiratory distress and acute lung injury,and it is one of the main causes of death within 6 hours after blood transfusion,with a fatality rate of 5%-10%.The pathological mechanism of TRALI is divided into antibody-mediated and non-antibody-mediated,and the research on the“two-hit”model of its pathogenesis has been more and more recognized.However,there is no clear treatment for TRALI.In this paper,the pathogenesis and prevention measures of TRALI were described..
作者
白钰婷
何一轩
刘国权
顾玮
Bai Yuting;He Yixuan;Liu Guoquan;Gu Wei(School of postgraduate,Bengbu Medical College,Bengbu,Anhui,233030,China)
出处
《齐齐哈尔医学院学报》
2022年第20期1942-1947,共6页
Journal of Qiqihar Medical University
基金
国家自然科学基金(82104178)
安徽省教育厅重点项目(KJ2021A0768)
蚌埠医学院科研创新团队项目(BYKC201903)。
关键词
输血相关急性肺损伤
临床表现
病理机制
预防
治疗策略
Transfusion-related acute lung injury
Clinical manifestation
Pathomechanism
Prevention
Therapeutic strategy
