摘要
心肌重构是多种心脏疾病的最终结局,寻找有效的措施干预心肌重构过程具有重要意义。血小板反应蛋白(TSP)属于TSP家族的细胞外基质(ECM)蛋白,由5个成员组成。在TSP中,TSP-1、TSP-2和TSP-4是研究最多和功能测试最多的成员。TSP-1具有抗血管生成活性,能够激活转化生长因子-β(TGF-β),是一种有效的促纤维化和抗炎因子。TSP-2和TSP-4都参与了肥厚心脏ECM成分的控制。本文就TSP的结构及其在心肌重构中的作用以及与这些TSP相关的潜在途径进行综述,以期为心肌重构的治疗提供一定的帮助。
Myocardial remodeling is the final outcome of a variety of heart diseases. It is of great significance to find effective measures to intervene myocardial remodeling. Thrombospondin(TSP) is an extracellular matrix(ECM) protein belonging to the TSP family, which consists of five members. Among the TSPs, TSP-1, TSP-2, and TSP-4 are functionally tested. TSP-1 has anti-angiogenic activity and can activate transforming growth factor-β(TGF-β),which is a potent pro-fibrotic and anti-inflammatory factor. Both TSP-2and TSP-4 are involved in the control of ECM components in hypertrophic hearts. This paper reviews the structure and role of TSP and myocardial remodeling, as well as the potential pathways related to these TSPs,in order to provide some help for the treatment of myocardial remodeling.
作者
郑常松
吕云波
王辉波
陈惠
ZHENG Changsong;LYU Yunbo;WANG Huibo;CHEN Hui(Cardiology Department,People's Hospital of China Three Gorges University,the First People's Hospital of Yichang,Yichang 443000,China)
出处
《生命的化学》
CAS
2022年第10期1858-1865,共8页
Chemistry of Life
基金
湖北省自然科学基金项目(2021CFB202)。
