SIRT家族在胰腺癌中的作用及研究现状

Role and research progress of SIRT family in pancreatic cancer

胰腺癌是常见消化系统恶性肿瘤之一,由于其恶性程度高、侵袭转移能力强,目前胰腺癌患者总体生存率低。沉默信息调节因子(Sirtuins,SIRTs)家族是一组高度保守的烟酰胺腺嘌呤二核苷酸依赖的Ⅲ类组蛋白去乙酰化酶,具有去乙酰酶活性,参与多种生理、病理过程。近年来,研究发现,SIRTs在胰腺癌的发生发展中发挥重要作用。本文就SIRTs在胰腺癌发生发展中的作用及研究现状作系统综述,为胰腺癌发病机制研究提供新参考。

Pancreatic cancer is one of the common malignant tumors of digestive system. Due to its high degree of malignancy, invasion and metastasis, the overall survival rate of pancreatic cancer patients is low at present. Sirtuins family(SIRTs) is a group of highly conserved nicotinamide adenine dinucleotide dependent class III histone deacetylases, which have deacetylase activity and participate in a variety of physiological and pathological processes. In recent years, it has been found that SIRTs play an important role in the occurrence and development of pancreatic cancer. In this paper, the role and research status of SIRTs in the pathogenesis and development of pancreatic cancer are systematically reviewed, providing new reference for the pathogenesis of pancreatic cancer.