铁死亡在脓毒症中的研究进展

Research progress of ferroptosis in sepsis

脓毒症是一种严重损害健康的全身性疾病,2016年脓毒症被重新定义为由宿主对感染反应失调所导致的危及生命的器官功能障碍,是全球公共健康的优先事项。近年来,人们越来越认识到微量元素铁代谢失调在脓毒症发病机制中的作用。Dixon等在2012年首次提出了铁死亡的概念,这是一种依赖铁的、非凋亡的细胞死亡模式,其特征是脂质活性氧(ROS)的累积。铁死亡作为一种新型的细胞程序性死亡方式,在形态和生化特征上不同于凋亡、自噬、坏死、裂解等多种形式的细胞死亡。近年来的研究表明,铁死亡在脓毒症的发生发展中起着重要的调节作用,已成为相关疾病诊疗和改善预后的研究重点和热点。现将铁死亡在脓毒症中的最新研究进展进行概述,以期进一步了解其发病机制并为脓毒症所致相关器官功能障碍提供新的治疗靶点。

Sepsis is a systemic disease with severe health consequences,and it was redefined in 2016 as a life-threatening organ dysfunction caused by an abnormal host response to infection and is a global public health priority.In recent years,there has been increasing recognition of the role of dysregulated micronutrient iron metabolism in the pathogenesis of sepsis.The concept of ferroptosis,an iron-dependent,non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species(ROS),was first proposed by Dixon et al.in 2012.As a novel mode of programmed cell death,ferroptosis differs in morphological and biochemical characteristics from various forms of cell death,such as apoptosis,autophagy,necrosis and lysis.Recent studies have shown that ferroptosis plays an important regulatory role in the development of sepsis and has become a research focus and highlight for the diagnosis and prognosis of related diseases.Therefore,this paper reviews the latest developments in ferroptosis in sepsis,in order to further understanding its pathogenesis and providing new therapeutic targets for sepsis-related organ dysfunction.