平足蛋白在脓毒症中作用机制的研究进展

Research progress on the mechanism of role of podoplanin in sepsis

平足蛋白(PDPN)是一种小分子Ⅰ型跨膜黏蛋白样糖蛋白,表达于淋巴管内皮细胞、肾小球足细胞、Ⅰ型肺泡上皮细胞和某些肿瘤细胞等细胞表面,参与胚胎发育、免疫应答、炎症和癌症等多种生理和病理过程。C型凝集素样受体2(CLEC2)主要表达于血小板上,作为其唯一配体的PDPN可与CLEC2相互作用,在调控脓毒症的发病机制方面受到广泛关注。本文回顾分析近年来关于PDPN与脓毒症的研究,系统阐述PDPN参与脓毒症的可能机制以及针对PDPN治疗脓毒症的一些潜在措施,为深入研究PDPN和脓毒症的关系以及探索脓毒症的发生机制和临床干预措施提供理论依据。

Podoplanin(PDPN)is a small transmembrane mucin-like glycoprotein which is expressed on the surface of lymphatic endothelial cells,glomerular podocytes,type-Ⅰalveolar epithelial cells and some tumor cells.PDPN plays crucial function in variety of physiological and pathological processes such as embryonic development,immunoreaction,inflammation and cancer.C-type lectin-like receptor 2(CLEC2)is mainly expressed on the platelet which specific ligand is PDPN.The interaction between PDPN and CLEC2 has received extensive attention.In this review,we summarized recent researches on the role of in sepsis and elaborated the possible mechanisms and some potential therapies for sepsis by targeting PDPN,which may provide theoretical basis for the mechanism and treatment of sepsis.