可溶性fms样酪氨酸激酶-1及胎盘生长因子与子痫前期关系的研究进展

Research Progress on the Relationship Between Soluble Fms-like Tyrosine Kinase-1 and Placental growth Factor and Preeclampsia

子痫前期作为妊娠期高血压疾病(hypertensive disorders of Pregnancy,HDP)家族成员中的一种,是造成孕产妇产后大出血、胎盘早剥、胎儿生长发育受限等不好孕育结果的主要因素之一。作为一种多种因素共同致病的疾病,子痫前期的发病机制还未达成共识。近年来,更多的临床实验结果表明:在患有子痫或子痫前期的妊娠妇女血液标本中,包括了胎盘生长因子(placental growth factor,PLGF)、可溶性Fms样酪氨酸激酶-1(soluble fms-like tyrosin e kinase-1,sFlt-1)在内的多种生物标志物,存在着较正常未患病孕妇更为明显的浓度变化。本文主要针对sFlt-1、PLGF及其比值与子痫前期的相关关系进行综述。

Preeclampsia,a family member of hypertensive disorders of Pregnancy(HDP),is one of the most important diseases associated with hypertension during Pregnancy.PE,is one of the main factors causing postpartum hemorrhage,placental abruption,fetal growth and development restriction and other bad pregnancy results.As a multifactorial disease,the pathogenesis of preeclampsia has not been agreed.PLGF(Placental growth factor)and SOLUBLE FMS-like tyrosine(Soluble FMS-like tyrosine)were found in the blood samples of pregnant women with eclampsia or preeclampsia Kinase-1,(Sflt-1)and other biomarkers showed more obvious concentration changes than normal pregnant women without disease.This paper reviews the correlation between Sflt-1,PLGF and their ratio and preeclampsia.