血浆D-二聚体检验在急性白血病患者病情进展与疗效评估中临床应用价值

Clinical Application Value of Plasma D-dimer Test in Evaluation of Disease Progression and Curative Effect of Acute Leukemia Patients

目的急性白血病患者应用血浆D-二聚体检验判断病情进展与疗效评估中临床价值分析。方法于本院收治的急性白血病患者中筛选80例作为研究对象纳入观察组,另于同期本院进行健康体检者中随机选取80例作为对照研究对象纳入对照组中,两组研究对象均检测血浆D-二聚体水平(应用免疫比浊法)。对比疾病不同时期患者血浆D-二聚体水平和对照组之间的差异,判断急性白血病患者应用血浆D-二聚体对疾病进展和治疗效果评估的应用价值。结果治疗后未缓解组及缓解和对照组比较组间差异显著(P<0.05),缓解组血浆D-二聚体水平高于未缓解组(t=7.319,P=0.000),缓解组血浆D-二聚体水平高于对照组(t=12.068,P=0.000),未缓解组血浆D-二聚体水平高于对照组(t=20.409,P=0.000);治疗后缓解组D-二聚体水平低于治疗前(t=6.335,P=0.000),未缓解组D-二聚体水平低于治疗前(t=3.755,P=0.000),未缓解组D-二聚体水平高于对照组(t=15.714,P=0.000),缓解组D-二聚体水平高于对照组(t=1.799,P=0.074),组间差异无明显统计学意义(P>0.05)。两组干预前白血病患者特异性生活质量量表评分无明显差异(P>0.05)。两组干预后白血病患者特异性生活质量量表评分均比治疗前降低(P<0.05),且观察组缓解组比观察组未缓解组降低更明显,差异有统计学意义(P<0.05)。在本次研究结果中显示,观察组缓解组患者的各项生活质量评分明显优于观察组未缓解组,组间对比分析差异显著(P<0.05)。结论急性白血病患者可将血浆D-二聚体水平作为判断疾病变化的重要依据,可通过动态检测血浆D-二聚体水平对患者疾病进展进行准确判断或是作为评定治疗效果的有力依据,应用价值显著值得重视。

Objective To analyze clinical value of plasma D-dimer detection in evaluation of disease progression and curative effect of acute leukemia patients.Methods The paper chose 80 cases acute leukemia patients in our hospital as study subjects in observation group,and another 70 cases with health checkups in our hospital at the same time randomly as control study subjects.Plasma D-dimer levels were detected in both groups(with immune turbidimetry).Difference of plasma D-dimer level of patients at different stages of disease was compared between two groups,and application value of plasma D-dimer of patients with acute leukemia for disease progress was determined,and treatment effect was evaluated.Results Before treatment,there was significant difference between non remission group and remission group and control group(P<0.05).Plasma D-dimer level in remission group was higher than non remission group(t=7.319,P=0.000),plasma D-dimer level in remission group was higher than control group(t=12.068,P=0.000),and plasma D-dimer level in non remission group was higher than control group(t=20.409,P=0.000).After treatment,D-dimer level in remission group was lower than before treatment(t=6.335,P=0.000),D-dimer level in non remission group was lower than before treatment(t=3.755,P=0.000),D-dimer level in non remission group was higher than control group(t=15.714,P=0.000),and D-dimer level in remission group was higher than control group(t=1.799,P=0.074).There was no significant difference between groups(P>0.05),no significant difference between two groups in specific life quality scale scoress of rectal cancer patients before intervention(P>0.05).Specific life quality scale scores of rectal cancer patients in two groups after intervention were lower than before treatment(P<0.05).Study results showed that life quality scores in remission group of observation group were significantly better than non remission group of observation group,difference between groups was significant(P<0.05).Conclusion Plasma D-dimer level can be important basis to judge disease changes of patients with acute leukemia,and dynamic detection of plasma D-dimer level can be powerful basis to judge disease progress of patients accurately or evaluate curative effect,which has significant application value.